Document Detail


Chronic demyelination inhibits remyelination in the central nervous system. An analysis of contributing factors.
MedLine Citation:
PMID:  7442125     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The remyelinative capacity of the central nervous system was investigated in the superior cerebellar peduncles of mice chronically demyelinated for 6 to 7 months by the administration of Cuprizone. It was found that, although the axons retained their capacity for remyelination, this capacity was greatly reduced compared to acutely demyelinated animals. The possible causes for this reduction were examined, and it was concluded that the limiting factor was the decreased availability of oligodendrocytes for remyelination, rather than inherent factors in the axons, or changes in the surrounding glial environment. The implications for both experimental and clinical disease are discussed.
Authors:
S K Ludwin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Laboratory investigation; a journal of technical methods and pathology     Volume:  43     ISSN:  0023-6837     ISO Abbreviation:  Lab. Invest.     Publication Date:  1980 Oct 
Date Detail:
Created Date:  1981-02-26     Completed Date:  1981-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376617     Medline TA:  Lab Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  382-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Astrocytes / pathology
Axons / ultrastructure
Central Nervous System
Cerebellum / ultrastructure
Chronic Disease
Cuprizone
Demyelinating Diseases / chemically induced,  pathology*
Male
Mice
Microscopy, Electron
Myelin Sheath / pathology
Oligodendroglia / pathology
Chemical
Reg. No./Substance:
370-81-0/Cuprizone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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