Document Detail

Chronic decrease of blood pressure by rat relaxin in spontaneously hypertensive rats.
MedLine Citation:
PMID:  4046737     Owner:  NLM     Status:  MEDLINE    
Relaxin is an ovarian polypeptide hormone which is present in large amounts in the rat during the second half of gestation. During this period, blood pressure declines markedly, especially in spontaneously-hypertensive rats (SHR). To test the hypothesis that relaxin might be implicated in this decrease in blood pressure, we infused the hormone in female non-pregnant rats by means of an osmotic mini pump. Our results show that intravenous infusion of purified rat relaxin (1.8 micrograms/day) markedly reduced systolic blood pressure for at least 5 or 6 days in SHR. This decrease was highly significant from 24 hours after the beginning of the infusion and remained significant after 5 days. Rat relaxin was ineffective in control Wistar-Kyoto rats (WKY). Infusion of purified porcine relaxin (3.0 micrograms/day) also diminished blood pressure in SHR, but the effect was less pronounced and developed more slowly, reaching statistical significance on the fourth day of infusion. SHR not receiving relaxin maintained their original systolic blood pressure throughout the experiment. These results indicate that relaxin is involved in the regulation of blood pressure during gestation.
J St-Louis; G Massicotte
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  37     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-10-30     Completed Date:  1985-10-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1351-7     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects*
Hypertension / physiopathology*
Rats, Inbred SHR
Rats, Inbred WKY
Relaxin / blood,  pharmacology*
Reg. No./Substance:

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