Document Detail

Chronic daily headache--one disease or two? Diagnostic role of serum ionized magnesium.
MedLine Citation:
PMID:  8200019     Owner:  NLM     Status:  MEDLINE    
The entity of chronic daily headache (CDH) is well documented, but is not included in the current classification. We divided patients with CDH into groups with and without migrainous features. This division resulted in clearly distinguishable syndromes of daily migrainous headaches (DMH) and daily tension-type headaches (DTH). Family history of headaches was more common in patients with DMH. Patients in both groups had a high incidence of caffeine or drug overuse. The clinical division into DMH and DTH was supported by our finding of a higher incidence of disturbed magnesium (Mg) metabolism in patients with DMH. Of 26 patients with DMH, 8 (30.8%) had low serum ionized, but not total, Mg levels, and 16 (61.5%) had high ionized calcium/magnesium ratios. The corresponding numbers for the 22 patients with DTH were 1 (4.5%) and 8 (36.4%). These new laboratory measurements offer possible biological markers for the diagnosis of different headache syndromes.
A Mauskop; B T Altura; R Q Cracco; B M Altura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cephalalgia : an international journal of headache     Volume:  14     ISSN:  0333-1024     ISO Abbreviation:  Cephalalgia     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-07-07     Completed Date:  1994-07-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8200710     Medline TA:  Cephalalgia     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  24-8     Citation Subset:  IM    
Department of Neurology, State University of New York, Health Science Center at Brooklyn 11203-2098.
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MeSH Terms
Aged, 80 and over
Biological Markers / blood
Caffeine / adverse effects
Chronic Disease
Diagnosis, Differential
Headache / blood*,  classification*,  diagnosis,  etiology
Magnesium / blood*
Middle Aged
Migraine Disorders / blood,  diagnosis
Sex Factors
Stress, Physiological / complications
Substance-Related Disorders / complications
Reg. No./Substance:
0/Biological Markers; 58-08-2/Caffeine; 7439-95-4/Magnesium

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