| Chronic cyanosis and vascular function: implications for patients with cyanotic congenital heart disease. | |
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MedLine Citation:
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PMID: 20416139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In patients with cyanotic congenital heart disease, chronic hypoxaemia leads to important changes in blood vessel function and structure. Some of these alterations are maladaptive and probably contribute to impaired cardiopulmonary performance and an increased incidence of thrombotic and embolic events. Recent evidence suggests that deranged endothelial function, a sequel of chronic cyanosis, could be an important factor in the pathogenesis of cyanosis-associated cardiovascular risk. In this article, we discuss the physiological and mechanical consequences of compensatory erythrocytosis and possible pathophysiological mechanisms of vascular dysfunction in chronic cyanosis. |
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Authors:
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Rachael L Cordina; David S Celermajer |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-04-26 |
Journal Detail:
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Title: Cardiology in the young Volume: 20 ISSN: 1467-1107 ISO Abbreviation: Cardiol Young Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-12 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200019 Medline TA: Cardiol Young Country: England |
Other Details:
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Languages: eng Pagination: 242-53 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Royal Prince Alfred Hospital and University of Sydney, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anoxia
/
blood,
complications*,
physiopathology Blood Viscosity Chronic Disease Cyanosis / etiology*, physiopathology Disease Progression Endothelium, Vascular / physiopathology* Heart Defects, Congenital / complications*, physiopathology Humans Microcirculation Muscle, Smooth, Vascular / physiopathology* Polycythemia / blood, complications, physiopathology Vascular Diseases / complications, physiopathology* Vasoconstriction / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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