| Chronic consumption of distilled sugarcane spirit induces anxiolytic-like effects in mice. | |
| | |
MedLine Citation:
|
PMID: 21789394 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: Chronic ethanol consumption is a major public health problem throughout the world. We investigated the anxiolytic-like effects and the possible ever injury induced by the chronic consumption of ethanol or sugarcane spirit in mice. METHOD: Adult mice were exposed to a two-bottle free-choice paradigm for 6 weeks. The mice in Group A (n = 16) had access to sugarcane spirit + distilled water, the mice in Group B (n = 15) had access to ethanol + distilled water, and the mice in Group C (control, n = 14) had access to distilled water + distilled water. The ethanol content in the beverages offered to Groups A and B was 2% for the first week, 5% for the second week and 10% for the remaining four weeks. At the end of the experimental period, the mice were evaluated using the elevated-plus maze and the hole-board test to assess their anxiety-related behaviors. We also determined the serum aspartate aminotransferase and alanine aminotransferase levels. RESULTS: In the elevated-plus maze, the time spent in the open arms was increased in the mice exposed to chronic ethanol (32 + 8 vs. 7 + 2 s, n = 9) or sugarcane spirit (36 + 9 vs. 7 + 2 s, n = 9) compared to the controls. In the hole-board test, the mice exposed to ethanol or sugarcane spirit displayed increases in their head-dipping frequency (16 + 1 for the control group, 27 + 2 for the ethanol group, and 31 + 3 for the sugarcane-spirit group; n = 9 for each group). In addition, the mice exposed to sugarcane spirit displayed an increase in the aspartate aminotransferase / alanine aminotransferase ratio compared to the ethanol group (1.29 + 0.17 for the control group and 2.67 + 0.17 for the sugarcane spirit group; n = 8 for each group). CONCLUSION: The chronic consumption of sugarcane-spirit produces liver injury and anxiolytic-like effects and the possible liver injury in mice. |
| | |
Authors:
|
Maria Clecia P Sena; Fabíola C Nunes; Mirian G S Stiebbe Salvadori; Cleyton Charles D Carvalho; Liana Clebia S L Morais; Valdir A Braga |
Related Documents
:
|
23607774 - Effects of high potassium chloride supplementation on water intake and bodyweight gains... 11442744 - A comprehensive guide for the accurate classification of murine hair follicles in disti... 8839234 - Effects of transforming growth factor beta 1 in the hair cycle. 1836514 - Hairpatches, a single gene mutation characterized by progressive renal disease and alop... 8100454 - Failure of cryptorchidism to suppress fertility in a tropical rodent. 11787734 - Regulation of cell apoptosis by insulin-like growth factor i. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinics (São Paulo, Brazil) Volume: 66 ISSN: 1980-5322 ISO Abbreviation: Clinics (Sao Paulo) Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-07-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101244734 Medline TA: Clinics (Sao Paulo) Country: Brazil |
Other Details:
|
Languages: eng Pagination: 873-8 Citation Subset: IM |
Affiliation:
|
Laboratory of Pharmaceutical Technology, Federal University of Paraíba, João Pessoa, PB, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological stud...
Next Document: The effect of Nigella sativa extract on tracheal responsiveness and lung inflammation in ovalbumin-s...