Document Detail

Chronic consumption of distilled sugarcane spirit induces anxiolytic-like effects in mice.
MedLine Citation:
PMID:  21789394     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Chronic ethanol consumption is a major public health problem throughout the world. We investigated the anxiolytic-like effects and the possible ever injury induced by the chronic consumption of ethanol or sugarcane spirit in mice.
METHOD: Adult mice were exposed to a two-bottle free-choice paradigm for 6 weeks. The mice in Group A (n = 16) had access to sugarcane spirit + distilled water, the mice in Group B (n = 15) had access to ethanol + distilled water, and the mice in Group C (control, n = 14) had access to distilled water + distilled water. The ethanol content in the beverages offered to Groups A and B was 2% for the first week, 5% for the second week and 10% for the remaining four weeks. At the end of the experimental period, the mice were evaluated using the elevated-plus maze and the hole-board test to assess their anxiety-related behaviors. We also determined the serum aspartate aminotransferase and alanine aminotransferase levels.
RESULTS: In the elevated-plus maze, the time spent in the open arms was increased in the mice exposed to chronic ethanol (32 ± 8 vs. 7 ± 2 s, n = 9) or sugarcane spirit (36 ± 9 vs. 7 ± 2 s, n = 9) compared to the controls. In the hole-board test, the mice exposed to ethanol or sugarcane spirit displayed increases in their head-dipping frequency (16 ± 1 for the control group, 27 ± 2 for the ethanol group, and 31 ± 3 for the sugarcane-spirit group; n = 9 for each group). In addition, the mice exposed to sugarcane spirit displayed an increase in the aspartate aminotransferase / alanine aminotransferase ratio compared to the ethanol group (1.29 ± 0.17 for the control group and 2.67 ± 0.17 for the sugarcane spirit group; n = 8 for each group).
CONCLUSION: The chronic consumption of sugarcane-spirit produces liver injury and anxiolytic-like effects and the possible liver injury in mice.
Maria Clecia P Sena; Fabíola C Nunes; Mirian G S Stiebbe Salvadori; Cleyton Charles D Carvalho; Liana Clebia S L Morais; Valdir A Braga
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  66     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-26     Completed Date:  2012-06-08     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  873-8     Citation Subset:  IM    
Laboratory of Applied Physiology, Veterinary Sciences Department, Center for Agrarian Sciences, Federal University of Paraíba, Areia, PB, Brazil.
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MeSH Terms
Alanine Transaminase / blood
Alcoholic Beverages*
Anxiety / chemically induced,  psychology*
Aspartate Aminotransferases / blood
Central Nervous System Depressants / pharmacology*
Ethanol / pharmacology*
Liver / drug effects,  growth & development,  pathology
Mice, Inbred C57BL
Saccharum / chemistry*
Time Factors
Reg. No./Substance:
0/Central Nervous System Depressants; 64-17-5/Ethanol; EC Aminotransferases; EC Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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