| Chronic constipation in hypercalcemic patients with primary hyperparathyroidism. | |
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MedLine Citation:
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PMID: 22953636 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Chronic constipation (C), among gastrointestinal symptoms, is commonly associated with primary hyperparathyroidism (PHPT) and probably attributable to hypercalcemia. OBJECTIVE OF THE STUDY: To evaluate in patients affected with PHPT the prevalence of C utilizing a validated questionnaire and the current prevalence of C compared to that observed in the past and to evaluate the relationship between C and the severity of PHPT. METHODS: 55 outpatients affected with PHPT, admitted to our Department of Internal Medicine and Medical Specialities in the years (2006-2009) were studied (group 1: 50 postmenopausal women and 5 men, mean age 61.9 +/- 9.4 years), together with 55 sex and age matched controls (group 2). Also considered were a group of PHPT patients observed, in the same ambulatory, during the years '70-'80 (group 3). A questionnaire, Rome II criteria, was administered and used to define C, whereas only anamneses were used to define C in group 3. RESULTS: The prevalence of C in patients with PHPT was 21.8% in group 1 vs 12.7% in group 2 (n.s.) and 32.7% in group 3. There is a decreasing trend in the prevalence of C in patients with PHPT as observed from 1970-89 to 2006-2009 (p < 0.05). The reduction of C was associated together with a significant reduction in the serum calcium level (p < 0.001). The presence of C vs its absence in patients with PHPT is characterized by higher values of calcemia (p < 0.001), ionized calcium (p < 0.001), and parathyroid hormone (p = 0.019). CONCLUSION: The actual prevalence of C in patients with PHPT is not significantly different from that found in the control group and is decreasing with respect to the past years. Moreover, C seems to be associated with the severity of the disease rather than with the diagnosis of PHPT per se. |
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Authors:
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A Ragno; J Pepe; D Badiali; S Minisola; E Romagnoli; C Severi; E D'Erasmo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European review for medical and pharmacological sciences Volume: 16 ISSN: 1128-3602 ISO Abbreviation: Eur Rev Med Pharmacol Sci Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-09-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9717360 Medline TA: Eur Rev Med Pharmacol Sci Country: Italy |
Other Details:
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Languages: eng Pagination: 884-9 Citation Subset: IM |
Affiliation:
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Unit of Internal Medicine, Nuovo Regina Apostolorum Hospital, Albano Laziale, Italy. |
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