| Chronic cold agglutinin disease of the "idiopathic" type is a premalignant or low-grade malignant lymphoproliferative disease. | |
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MedLine Citation:
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PMID: 9201236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the clinical, pathological, and immunological features of "idiopathic" cold agglutinin disease (CAD) in a population-based study. Fourteen patients were studied, giving a prevalence of about 14 per million with a mean age of 75 years. Haemolysis was present in all cases, but only eight patients had clinical symptoms of peripheral haemagglutination. Serum electrophoresis, immunofixation, morphological bone marrow evaluation, and flow cytometric immunophenotyping were used to detect any monoclonal lymphoproliferative disorder. Flow cytometry seemed to be a sensitive way to demonstrate a clonal B-cell proliferation. Some evidence of clonality was found in 13 patients, and a clonal lymphoproliferative disease was documented by flow cytometry or biopsy in 10 out of 11 patients. We conclude that CAD is a symptom-producing monoclonal lymphoproliferative disorder in nearly all patients. |
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Authors:
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S Berentsen; K Bø; F V Shammas; A O Myking; E Ulvestad |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica Volume: 105 ISSN: 0903-4641 ISO Abbreviation: APMIS Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-07-22 Completed Date: 1997-07-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8803400 Medline TA: APMIS Country: DENMARK |
Other Details:
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Languages: eng Pagination: 354-62 Citation Subset: IM |
Affiliation:
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Department of Medicine, Haukeland University Hospital, Bergen, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Anemia, Hemolytic, Autoimmune / immunology*, pathology, physiopathology, therapy Chronic Disease Female Humans Immunophenotyping Lymphoproliferative Disorders / immunology*, pathology, physiopathology Male Middle Aged Precancerous Conditions / immunology*, pathology, physiopathology, therapy Prospective Studies Retrospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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