| Chronic clenbuterol administration negatively alters cardiac function. | |
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MedLine Citation:
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PMID: 11932573 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Chronic administration of pharmacological levels of beta2-agonists have been shown to have toxic effects on the heart; however, no data exist on cardiac function after chronic clenbuterol administration. The purpose of this study was to examine the effect of therapeutic levels of clenbuterol on cardiac performance. METHODS: Twenty unfit Standardbred mares were divided into four experimental groups: clenbuterol (2.4 microg.kg(-1) twice daily 5 d.wk(-1)) plus exercise (20 min at 50% .VO(2max)) (CLENEX; N = 6), clenbuterol (CLEN; N = 6), exercise (EX; N = 4), and control (CON; N = 4). M-mode and two-dimensional echocardiography (2.5-MHz sector scanner transducer) were used to measure cardiac size and function before and immediately after an incremental exercise test, before and after 8 wk of drug and/or exercise treatments. RESULTS: After treatment, CLENEX and CLEN demonstrated significantly higher left ventricular internal dimension (LVD) at end diastole (+23.7 +/- 4.8%; +25.6 +/- 4.1%), LVD at end systole (+29.2 +/- 8.7%; +40.1 +/- 7.9%), interventricular septal wall thickness (IVS) at end diastole (+28.9 +/- 11.0%; +30.7 +/- 7.0%), IVS at end systole (+29.2 +/- 8.7%; +40.1 +/- 7.9%), and left ventricular posterior wall systolic thickness (+43.1 +/- 14.%; +45.8 +/- 14.1%). CLENEX and CLEN had significantly increased aortic root dimensions (+29.9 +/- 6.1%; +24.0 +/- 1.7%), suggesting increased risk of aortic rupture. CONCLUSION: Taken together, these data indicate that chronic clenbuterol administration may negatively alter cardiac function. |
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Authors:
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Margaret M Sleeper; Charles F Kearns; Kenneth H McKeever |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 34 ISSN: 0195-9131 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-04-04 Completed Date: 2002-04-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
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Languages: eng Pagination: 643-50 Citation Subset: IM; S |
Affiliation:
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University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Agonists
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administration & dosage,
adverse effects* Animals Aorta, Thoracic / pathology, ultrasonography Clenbuterol / administration & dosage, adverse effects* Echocardiography, Stress Female Heart / drug effects*, physiopathology* Heart Ventricles / drug effects, pathology Horses Myocardium / pathology Physical Conditioning, Animal / physiology Rest / physiology Ventricular Remodeling* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 37148-27-9/Clenbuterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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