Document Detail

Chronic clenbuterol administration negatively alters cardiac function.
MedLine Citation:
PMID:  11932573     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Chronic administration of pharmacological levels of beta2-agonists have been shown to have toxic effects on the heart; however, no data exist on cardiac function after chronic clenbuterol administration. The purpose of this study was to examine the effect of therapeutic levels of clenbuterol on cardiac performance. METHODS: Twenty unfit Standardbred mares were divided into four experimental groups: clenbuterol (2.4 twice daily 5 d.wk(-1)) plus exercise (20 min at 50% .VO(2max)) (CLENEX; N = 6), clenbuterol (CLEN; N = 6), exercise (EX; N = 4), and control (CON; N = 4). M-mode and two-dimensional echocardiography (2.5-MHz sector scanner transducer) were used to measure cardiac size and function before and immediately after an incremental exercise test, before and after 8 wk of drug and/or exercise treatments. RESULTS: After treatment, CLENEX and CLEN demonstrated significantly higher left ventricular internal dimension (LVD) at end diastole (+23.7 +/- 4.8%; +25.6 +/- 4.1%), LVD at end systole (+29.2 +/- 8.7%; +40.1 +/- 7.9%), interventricular septal wall thickness (IVS) at end diastole (+28.9 +/- 11.0%; +30.7 +/- 7.0%), IVS at end systole (+29.2 +/- 8.7%; +40.1 +/- 7.9%), and left ventricular posterior wall systolic thickness (+43.1 +/- 14.%; +45.8 +/- 14.1%). CLENEX and CLEN had significantly increased aortic root dimensions (+29.9 +/- 6.1%; +24.0 +/- 1.7%), suggesting increased risk of aortic rupture. CONCLUSION: Taken together, these data indicate that chronic clenbuterol administration may negatively alter cardiac function.
Margaret M Sleeper; Charles F Kearns; Kenneth H McKeever
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  34     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-04     Completed Date:  2002-04-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  643-50     Citation Subset:  IM; S    
University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, USA.
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MeSH Terms
Adrenergic beta-Agonists / administration & dosage,  adverse effects*
Aorta, Thoracic / pathology,  ultrasonography
Clenbuterol / administration & dosage,  adverse effects*
Echocardiography, Stress
Heart / drug effects*,  physiopathology*
Heart Ventricles / drug effects,  pathology
Myocardium / pathology
Physical Conditioning, Animal / physiology
Rest / physiology
Ventricular Remodeling*
Reg. No./Substance:
0/Adrenergic beta-Agonists; 37148-27-9/Clenbuterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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