Document Detail


Chronic cigarette smoking modulates injury and short-term recovery of the medial temporal lobe in alcoholics.
MedLine Citation:
PMID:  18178068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Memory function is largely mediated by the medial temporal lobe (MTL), and its compromise has been observed in alcohol dependence and chronic cigarette smoking. The effects of heavy alcohol consumption and chronic smoking on hippocampal volumes and MTL metabolites and their recovery during abstinence from alcohol have not been assessed. Male alcoholics in treatment (ALC) [13 smokers (sALC) and 11 non-smokers (nsALC)] underwent quantitative magnetic resonance imaging and short-echo proton magnetic resonance spectroscopic imaging at 1 week and 1 month of sobriety. Outcome measures were compared with 14 age-matched, non-smoking light-drinkers and were related to visuospatial learning and memory. Over 1 month of abstinence, N-acetyl-aspartate, a neuronal marker, and membrane-associated choline-containing metabolites normalized in the MTL of nsALC subjects, but remained low in the MTL of sALC subjects. Metabolite concentration changes in both groups were associated with improvements in visuospatial memory. Hippocampal volumes increased in both groups during abstinence, but increasing volumes correlated with visuospatial memory improvements only in nsALC subjects. In summary, chronic cigarette smoking in alcohol-dependent men appears to have adverse effects on MTL metabolite recovery during short-term sobriety. These data may also have implications for other conditions with established MTL involvement and significant smoking co-morbidity, such as schizophrenia-spectrum and mood disorders.
Authors:
Stefan Gazdzinski; Timothy C Durazzo; Ping-Hong Yeh; Dawn Hardin; Peter Banys; Dieter J Meyerhoff
Related Documents :
6800438 - Effects of alcohol and smoking on blood lead in middle-aged british men.
18425058 - Alterations of the tear film and ocular surface health in chronic smokers.
1455158 - Long-term smoking increases transcapillary escape rate of albumin.
1115928 - Peak expiratory flow in youths with varying cigarette smoking habits.
12821968 - Association between fruit and vegetable intake and change in body mass index among a la...
20803568 - An anatomical ultrasound study of the long posterior sacro-iliac ligament.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Psychiatry research     Volume:  162     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-04     Completed Date:  2008-05-16     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  133-45     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Alcohol Amnestic Disorder / pathology,  physiopathology*,  rehabilitation
Alcoholism / pathology,  physiopathology*,  rehabilitation
Aspartic Acid / analogs & derivatives,  metabolism
Atrophy
Choline / metabolism
Cross-Sectional Studies
Dominance, Cerebral / physiology
Energy Metabolism / physiology*
Hippocampus / pathology,  physiopathology
Humans
Image Processing, Computer-Assisted*
Magnetic Resonance Imaging*
Magnetic Resonance Spectroscopy*
Mental Recall / physiology
Middle Aged
Neuropsychological Tests
Smoking / adverse effects*
Temporal Lobe / pathology,  physiopathology*
Grant Support
ID/Acronym/Agency:
AA 10788/AA/NIAAA NIH HHS; R01 AA010788/AA/NIAAA NIH HHS; R01 AA010788-06/AA/NIAAA NIH HHS; R01 AA010788-07/AA/NIAAA NIH HHS; R01 AA010788-08/AA/NIAAA NIH HHS; R01 AA010788-09/AA/NIAAA NIH HHS; R01 AA010788-10/AA/NIAAA NIH HHS; R01 AA010788-11/AA/NIAAA NIH HHS; R01 AA010788-12/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
30KYC7MIAI/Aspartic Acid; 997-55-7/N-acetylaspartate; N91BDP6H0X/Choline
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The effect of a low glycemic load diet on acne vulgaris and the fatty acid composition of skin surfa...
Next Document:  Action of Humicola lanuginosa lipase on mixed monomolecular films of tricaprylin and polyethylene gl...