Document Detail

Chronic cigarette smoking modulates injury and short-term recovery of the medial temporal lobe in alcoholics.
MedLine Citation:
PMID:  18178068     Owner:  NLM     Status:  MEDLINE    
Memory function is largely mediated by the medial temporal lobe (MTL), and its compromise has been observed in alcohol dependence and chronic cigarette smoking. The effects of heavy alcohol consumption and chronic smoking on hippocampal volumes and MTL metabolites and their recovery during abstinence from alcohol have not been assessed. Male alcoholics in treatment (ALC) [13 smokers (sALC) and 11 non-smokers (nsALC)] underwent quantitative magnetic resonance imaging and short-echo proton magnetic resonance spectroscopic imaging at 1 week and 1 month of sobriety. Outcome measures were compared with 14 age-matched, non-smoking light-drinkers and were related to visuospatial learning and memory. Over 1 month of abstinence, N-acetyl-aspartate, a neuronal marker, and membrane-associated choline-containing metabolites normalized in the MTL of nsALC subjects, but remained low in the MTL of sALC subjects. Metabolite concentration changes in both groups were associated with improvements in visuospatial memory. Hippocampal volumes increased in both groups during abstinence, but increasing volumes correlated with visuospatial memory improvements only in nsALC subjects. In summary, chronic cigarette smoking in alcohol-dependent men appears to have adverse effects on MTL metabolite recovery during short-term sobriety. These data may also have implications for other conditions with established MTL involvement and significant smoking co-morbidity, such as schizophrenia-spectrum and mood disorders.
Stefan Gazdzinski; Timothy C Durazzo; Ping-Hong Yeh; Dawn Hardin; Peter Banys; Dieter J Meyerhoff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Psychiatry research     Volume:  162     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-04     Completed Date:  2008-05-16     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  133-45     Citation Subset:  IM    
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MeSH Terms
Alcohol Amnestic Disorder / pathology,  physiopathology*,  rehabilitation
Alcoholism / pathology,  physiopathology*,  rehabilitation
Aspartic Acid / analogs & derivatives,  metabolism
Choline / metabolism
Cross-Sectional Studies
Dominance, Cerebral / physiology
Energy Metabolism / physiology*
Hippocampus / pathology,  physiopathology
Image Processing, Computer-Assisted*
Magnetic Resonance Imaging*
Magnetic Resonance Spectroscopy*
Mental Recall / physiology
Middle Aged
Neuropsychological Tests
Smoking / adverse effects*
Temporal Lobe / pathology,  physiopathology*
Grant Support
AA 10788/AA/NIAAA NIH HHS; R01 AA010788/AA/NIAAA NIH HHS; R01 AA010788-06/AA/NIAAA NIH HHS; R01 AA010788-07/AA/NIAAA NIH HHS; R01 AA010788-08/AA/NIAAA NIH HHS; R01 AA010788-09/AA/NIAAA NIH HHS; R01 AA010788-10/AA/NIAAA NIH HHS; R01 AA010788-11/AA/NIAAA NIH HHS; R01 AA010788-12/AA/NIAAA NIH HHS
Reg. No./Substance:
30KYC7MIAI/Aspartic Acid; 997-55-7/N-acetylaspartate; N91BDP6H0X/Choline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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