| Chronic changes in blood flow alter endothelium-dependent responses in autogenous vein grafts in dogs. | |
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MedLine Citation:
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PMID: 7526008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Experiments were designed to determine the effects of blood flow on endothelium-dependent relaxations in canine vein grafts. METHODS: Blood flow through reversed femoral vein grafts was either increased by a distal arteriovenous fistula (increased flow), unmanipulated (normal flow), or reduced by a proximal adjustable clamp (reduced flow). Six weeks after implantation, blood flow through the graft was measured. Rings cut from grafts were suspended for the measurement of isometric force in organ chambers to determine endothelial function. RESULTS: Blood flow was significantly greater in grafts with a distal fistula compared to grafts with normal or decreased flow. Endothelium-dependent relaxations to acetylcholine were absent in all grafts. Endothelium-dependent relaxations to adenosine diphosphate, thrombin, and the calcium ionophore A23187 were less in grafts with reduced flow compared with grafts with increased flow. Relaxations to these agents in grafts with increased flow were reduced by an analog of L-arginine. Neointimal hyperplasia was increased in grafts with reduced flow. CONCLUSIONS: These data demonstrate that chronic diminution of blood flow decreases receptor-mediated release of endothelium-derived relaxing factors and increases neointimal hyperplasia in canine vein grafts. The production of endothelium-derived relaxing factors, one of which is nitric oxide, may influence the development of myointimal hyperplasia in vein grafts. |
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Authors:
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R A Cambria; R C Lowell; P Gloviczki; V M Miller |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter Volume: 20 ISSN: 0741-5214 ISO Abbreviation: J. Vasc. Surg. Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1994-12-27 Completed Date: 1994-12-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8407742 Medline TA: J Vasc Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 765-73 Citation Subset: IM |
Affiliation:
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Department of Surgery, Mayo Clinic and Foundation, Rochester, MN 55905. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Adenosine Diphosphate / pharmacology Adrenergic alpha-Agonists / pharmacology Animals Arginine / analogs & derivatives, pharmacology Arteriovenous Shunt, Surgical Blood Flow Velocity Calcimycin / pharmacology Constriction Dinoprost / pharmacology Dogs Endothelins / pharmacology Endothelium, Vascular / drug effects, pathology, physiopathology* Femoral Artery / drug effects, pathology, physiopathology*, surgery* Femoral Vein / drug effects, pathology, physiopathology*, transplantation* Hyperplasia Male Models, Biological Neovascularization, Pathologic / physiopathology Nitric Oxide / antagonists & inhibitors Quinoxalines / pharmacology Thrombin / pharmacology Tunica Intima / drug effects, pathology, physiopathology* Vascular Patency omega-N-Methylarginine |
| Grant Support | |
ID/Acronym/Agency:
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HL-42614/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Endothelins; 0/Quinoxalines; 10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; 51-84-3/Acetylcholine; 52665-69-7/Calcimycin; 551-11-1/Dinoprost; 58-64-0/Adenosine Diphosphate; 59803-98-4/brimonidine; 74-79-3/Arginine; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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