| Chronic but not acute oral L-arginine supplementation delays the ventilatory threshold during exercise in heart failure patients. | |
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MedLine Citation:
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PMID: 16258181 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to determine, in heart failure patients (HF), whether acute or chronic L-arginine supplementation (LAS) might delay the ventilatory threshold (VT) and whether chronic LAS might reduce exercise-induced plasma lactate increase. HF patients undertook 4 cardiopulmonary bicycle exercises tests. The first 3 were maximal without (EX(1)), after acute (EX(2)), or chronic (EX(3)) oral LAS (6 gm twice a day for 6 weeks). The 4th test (EX(4)) performed after chronic LAS, was similar to the first in order to investigate the effect of chronic LAS on circulating lactate levels. Results showed that acute LAS failed to improve both submaximal and maximal exercise capacities. Similarly, maximal exercise capacity remained unmodified after chronic LAS. Nevertheless, chronic LAS delayed significantly the patients' ventilatory threshold. Thus exercise duration prior to VT increased (mean +/- SEM) from 6.04 +/- 0.9 to 7.7 +/- 1.03 min (p = 0.04), resulting in a significant increase in oxygen uptake (1.05 +/- 0.08 to 1.24 +/- 0.12 L.min(-1); p = 0.03), CO(2) release (0.94 +/- 0.10 to 1.2 +/- 0.12 L.min(-1); p = 0.018), minute ventilation (29.31 +/- 2.8 to 34.5 +/- 2.7 L; p = 0.009), and workload (60.7 +/- 9.8 to 78.5 +/- 10.2 watts; p = 0.034). Furthermore, chronic LAS significantly reduced the exercise-induced increase in postexercise plasma lactate concentration (-21 +/- 7%). In conclusion, unlike acute supplementation, chronic LAS significantly delays the ventilatory threshold, and chronic LAS reduces circulating plasma lactate in HF patients. These data suggest that chronic LAS might improve the ability of HF patients to perform their daily-life activities. |
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Authors:
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Stéphane Doutreleau; Bertrand Mettauer; François Piquard; Adrien Schaefer; Evelyne Lonsdorfer; Ruddy Richard; Bernard Geny |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Canadian journal of applied physiology = Revue canadienne de physiologie appliquée Volume: 30 ISSN: 1066-7814 ISO Abbreviation: Can J Appl Physiol Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-10-31 Completed Date: 2005-11-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9306274 Medline TA: Can J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 419-32 Citation Subset: IM |
Affiliation:
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Service de Physiologie Clinique et d'Exploration Fonctionnelle, Hôpitaux Universitaires de Strasbourg, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anaerobic Threshold Arginine / administration & dosage*, pharmacology Carbon Dioxide Cardiac Output, Low / blood, physiopathology* Drug Administration Schedule Exercise* Exhalation Humans Lactic Acid / blood Male Middle Aged Osmolar Concentration Oxygen Consumption / drug effects Physical Endurance / drug effects Respiratory Mechanics / drug effects* Time Factors |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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