Document Detail


Chronic but not acute energy restriction increases intestinal nutrient transport in mice.
MedLine Citation:
PMID:  11238759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic energy restriction (ER) dramatically enhances intestinal absorption of nutrients by aged mice. Do adaptations in nutrient absorption develop only after extended ER or immediately after its initiation? To determine the time course of adaptations, we measured rates of intestinal glucose, fructose and proline transport 1-270 d after initiation of ER (70% of ad libitum) in 3-mo old mice. Mice of the same age that consumed food ad libitum (AL) served as controls; a third group was starved for 1 or 2 d only, to distinguish the effects of acute ER from those of starvation. Acute ER of 1, 2 and 10 d had no effect on nutrient absorption. Starvation significantly decreased intestinal mass per centimeter, thereby reducing transport per centimeter and intestinal absorptive capacity without significantly altering transport per milligram of intestine. ER for 24 d enhanced only fructose uptake, whereas ER for 270 d enhanced uptake of all nutrients by 20-100%. Despite marked differences in body weights, the wet weights of the stomach, small intestine, cecum and large intestine were generally similar in AL and ER mice, suggesting that the gastrointestinal tract was spared during ER. In contrast, the wet weights of the lungs, kidneys, spleen, heart, pancreas and liver each differed by 40-120% between ER and AL mice. Intestinal transport adaptations develop gradually during ER, and the main mechanism underlying these adaptations is a dramatic increase in transport activity per milligram tissue.
Authors:
R P Ferraris; Q X Cao; S Prabhakaram
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  131     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-12     Completed Date:  2001-04-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  779-86     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Physiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103-2714, USA. ferraris@umdnj.edu
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Biological*
Aging / physiology
Analysis of Variance
Animals
Biological Transport
Diet, Reducing
Energy Intake / physiology*
Food Deprivation / physiology*
Fructose / metabolism
Glucose / metabolism
Intestinal Absorption / physiology*
Intestines / metabolism*
Male
Mice
Mice, Inbred C57BL
Organ Size
Proline / metabolism
Time Factors
Grant Support
ID/Acronym/Agency:
AG11403/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
147-85-3/Proline; 30237-26-4/Fructose; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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