Document Detail

Chronic bullous dermatosis of childhood.
MedLine Citation:
PMID:  318816     Owner:  NLM     Status:  MEDLINE    
The clinical features, laboratory studies, and therapeutic responses of two boys with chronic bullous dermatosis of childhood are described. Direct immunofluorescent preparations of sections from a lesion, skin adjacent to a lesion, and uninvolved skin demonstrated linear deposition of IgA at the dermoepidermal junction in all three biopsy specimens from one patient. Similar preparations from the second child were negative for staining. No circulating antibodies to skin components were detected in either child by means of multiple substrates. Neither child had clinical manifestations nor laboratory findings suggestive of an associated gastrointestinal lesion; therefore, small bowel biopsies were not performed. Immunologic studies failed to demonstrate any of the abnormalities frequently described in dermatitis herpetiformis. Both boys responded dramatically to sulfapyridine therapy.
N B Esterly; N L Furey; B S Kirschner; R R Kretschmer; R M Septon
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  113     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1977 Jan 
Date Detail:
Created Date:  1977-02-26     Completed Date:  1977-02-26     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  42-6     Citation Subset:  AIM; IM    
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MeSH Terms
Age Factors
Child, Preschool
Chronic Disease
Dermatitis Herpetiformis / diagnosis
Immunoglobulin A / analysis
Immunoglobulin G / analysis
Skin / immunology
Skin Diseases, Vesiculobullous* / diagnosis,  drug therapy,  immunology
Sulfapyridine / therapeutic use
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 144-83-2/Sulfapyridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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