Document Detail

Chronic bradykinin infusion and receptor blockade in angiotensin II hypertension in rats.
MedLine Citation:
PMID:  10082495     Owner:  NLM     Status:  MEDLINE    
The influence of endogenous bradykinin(BK) on the control of arterial pressure and the development of cardiac hypertrophy was assessed in chronically angiotensin II(Ang II)-infused rats (200 ng. kg-1. min-1) through the effects of concomitant infusion of 3 doses of BK (15 ng. kg-1. d-1, 100 ng. kg-1. d-1 and 100 ng. kg-1. min-1 ie, 144 000 ng. kg-1. d-1) or BK-blockade by Hoe140 (300 microg. kg-1. d-1) for 10 days. In Ang II-infused rats, tail-cuff pressure increased from 124+/-3 to 174+/-6 mm Hg (P<0.001). The pressor effect of Ang II was not affected by simultaneous infusion of BK or Hoe140. At the end of the experiments, cardiac mass was higher in rats infused with Ang II alone (3.56+/-0.10 versus 2.89+/-0.05 mg/g in untreated controls, P<0.01) and the development of cardiac hypertrophy was not modified by administration of the 3 doses of BK or Hoe140. In addition, the fall in cardiac output associated with Ang II was prevented only by the moderate and high doses of BK, mainly through an increase in stroke volume and a decrease in total peripheral resistance. In the same way, the renal vasoconstrictor effect of Ang II was abolished by the medium and high dose of BK. Hoe140 did not affect cardiac output or renal blood flow in this model. No influence of BK or Hoe140 on the increase in albuminuria induced by Ang II was detected. In conclusion, exogenous BK may oppose the effect of Ang II on vascular tone, but it cannot prevent hypertension and target-organ damage associated with this experimental model of hypertension, even at a very high dose.
J L Pasquié; A Herizi; B Jover; A Mimran
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  33     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-04-13     Completed Date:  1999-04-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  830-4     Citation Subset:  IM    
Groupe Rein et Hypertension, Faculté de Médecine, Montpellier, France.
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MeSH Terms
Albuminuria / urine
Angiotensin II
Blood Pressure / drug effects
Bradykinin / administration & dosage,  analogs & derivatives,  pharmacology*
Disease Models, Animal
Hemodynamics / drug effects*
Hypertension / blood,  chemically induced,  metabolism*
Kidney / blood supply
Organ Size / drug effects
Potassium / blood
Rats, Sprague-Dawley
Receptors, Bradykinin / antagonists & inhibitors*
Reg. No./Substance:
0/Receptors, Bradykinin; 11128-99-7/Angiotensin II; 130308-48-4/icatibant; 58-82-2/Bradykinin; 7440-09-7/Potassium

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