| Chronic blood pressure and appetite responses to central leptin infusion in rats fed a high fat diet. | |
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MedLine Citation:
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PMID: 21311343 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: Obesity has been suggested to induce selective leptin resistance whereby leptin's anorexic effects are attenuated, whereas the effects to increase sympathetic nervous system activity and blood pressure remain intact. Most studies, however, have tested only the acute responses to leptin administration. This study tested whether feeding a high-fat diet causes resistance to the appetite and cardiovascular responses to chronic central leptin infusion. METHODS: Sprague-Dawley rats were fed high-fat diet (40% kcal from fat, n = 5) or normal-fat diet (13% kcal from fat, n = 5) for a year. Radiotelemeters were implanted for continuous monitoring of mean arterial pressure (MAP) and heart rate (HR). A 21G steel cannula was implanted in the lateral cerebral ventricle [intracerebroventricular (ICV)]. After recovery, leptin was infused ICV at 0.02 μg kg per min for 10 days. RESULTS: High-fat rats were heavier than normal-fat rats (582 ± 12 vs. 511 ± 19 g) and exhibited significantly higher MAP (114 ± 3 vs. 96 ± 7 mmHg). Although the acute (24 h) effects of leptin were attenuated in high-fat rats, chronic ICV leptin infusion decreased caloric intake in both groups similarly (50 ± 8 vs. 40 ± 10%) by day 5. Despite decreased food intake and weight loss, leptin infusion significantly increased MAP and HR in both high-fat and normal-fat rats (7 ± 2 and 5 ± 1 mmHg; 18 ± 11 and 21 ± 10 b.p.m., respectively). CONCLUSION: These results suggest that obesity induced by feeding a high-fat diet blunts the acute anorexic effects of leptin but does not cause significant resistance to the chronic central nervous system effects of leptin on appetite, MAP, or HR. |
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Authors:
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John H Dubinion; Alexandre A da Silva; John E Hall |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-9 |
Journal Detail:
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Title: Journal of hypertension Volume: - ISSN: 1473-5598 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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