Document Detail


Chronic autoimmune hemolytic anemia in children: a report of four patients.
MedLine Citation:
PMID:  7996066     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four children, ages seven to ten years, with direct antiglobulin test (DAT)-positive chronic hemolytic anemia are presented. The patients were followed for 3 to 10 years. Autoantibody against red cell antigens was nonspecific IgG type in all of the patients. In one of the four patients, anemia was associated with splenomegaly and jaundice. In this patient, the third component of the complement was also detected on the red cell surface. In one patient, serum IgA deficiency and frequent pulmonary infections were associated with the disease. This patient developed rheumatoid arthritis five years after diagnosis of hemolytic anemia. The third patient initially had thrombocytopenia subsequently developed DAT-positive hemolytic anemia, vitiligo and alopecia without any evidence of serologic changes suggestive of collagen vascular disorders. In these three patients, partial response was obtained with steroid therapy. The fourth patient developed DAT-positive hemolytic anemia twice during the five year follow-up period. Anemia resolved completely with steroid therapy in two months during the first episode, and in five months in the second. Generalized and peripheral lymphadenopathies which developed at the time of the second hemolytic anemia episode have persisted for the last three years. Administration of cyclosporine in two of the four patients did not result in any amelioration of the symptoms.
Authors:
F Duru; A Gürgey; M Cetin; T Kanra; C Altay
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of medicine     Volume:  25     ISSN:  0025-7850     ISO Abbreviation:  J Med     Publication Date:  1994  
Date Detail:
Created Date:  1995-01-17     Completed Date:  1995-01-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505566     Medline TA:  J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  231-40     Citation Subset:  IM    
Affiliation:
Dr. Sami Ulus Children's Hospital, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Anemia, Hemolytic, Autoimmune / complications,  immunology,  physiopathology*
Autoantibodies / analysis
Child, Preschool
Chronic Disease
Coombs' Test
Erythrocytes / immunology
Female
Follow-Up Studies
Humans
IgA Deficiency / etiology
Immunoglobulin G / analysis
Male
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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