Document Detail

Chronic atenolol treatment and hypertension development in spontaneously hypertensive rats.
MedLine Citation:
PMID:  631188     Owner:  NLM     Status:  MEDLINE    
Changes in systolic blood pressure (SBP), heart rate (HR), heart rate and plasma renin concentration (PRC) have been compared in three different groups of rats between the ages of 5 and 20 weeks. The groups were: spontaneously hypertensive rats (SHRs), atenolol-treated SHRs (200 mg/kg/day orally throughout the 15 weeks) and normotensive rats of the same strain (WKYs). Treatment with atenolol markedly inhibited the onset of genetic hypertension, reduced HR and PRC from the outset and diminished the heart weight/body weight ratio. Comparison of changes in these parameters in atenolol-treated SHRs, control SHRs and WKYs strongly suggests that the mechanism of atenolol's preventive action against hypertension development in SHRs primarily involves its effects on heart and on the renin--angiotensin system.
C Richer; J R Boissier; J F Giudicelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  47     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-05-24     Completed Date:  1978-05-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  393-400     Citation Subset:  IM    
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MeSH Terms
Atenolol / pharmacology*
Blood Pressure / drug effects*
Body Weight / drug effects
Heart / drug effects
Heart Rate / drug effects
Hypertension / genetics,  physiopathology*
Organ Size / drug effects
Propanolamines / pharmacology*
Renin / blood
Time Factors
Reg. No./Substance:
0/Propanolamines; 29122-68-7/Atenolol; EC

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