Document Detail

Chronic asymptomatic hyperamylasemia unrelated to pancreatic diseases.
MedLine Citation:
PMID:  21109499     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This study was addressed to assess the clinical characteristics of patients presenting with chronic hyperamylasemia unrelated to pancreatic diseases (CHUPD). Almost all patients presenting with chronic hyperamylasemia undergo expensive, long, difficult, and often unnecessarily repeated diagnostic procedures. This is in conjunction with the poor knowledge of the fact that besides hyperenzymemia secondary to pancreatic diseases and systemic illnesses, various non-pathological forms of chronic hyperamylasemia without relevant pathologic consequence can occur in clinical practice.
MATERIAL AND METHODS: Data of all patients with CHUPD were retrospectively reviewed (June 1997-December 2009). Fifty one patients were included in the study; median follow up was 48 months (range 8-112 months). Their pre-enrolment diagnoses were: chronic pancreatitis in 31 cases (60.7%) and recurrent pancreatitis in 13 cases (25.4%); the remaining 7 patients (13.7%) were without a specific diagnosis.
RESULTS: Our observations, supported by diagnostic procedures (Ca19-9 serum levels, abdominal ultrasonography, computed tomography and magnetic resonance, endoscopic retrograde cholangiopancreatography, and endoscopic ultrasonography) revealed that CHUPD was secondary to: a) benign pancreatic hyperamylasemia, 20 patients (39.2%); b) macroamylasemia, 18 patients (35.2 %) and c) salivary hyperamylasemia, 13 patients (25.4%).
CONCLUSIONS: Due to the poor familiarity with CHUPD, the occurrence of this condition quite frequently leads to unnecessarily repeated diagnostic procedures.
F Gallucci; R Buono; L Ferrara; E Madrid; S Miraglia; G Uomo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in medical sciences     Volume:  55     ISSN:  1898-4002     ISO Abbreviation:  Adv Med Sci     Publication Date:  2010  
Date Detail:
Created Date:  2010-12-20     Completed Date:  2011-04-08     Revised Date:  2012-02-08    
Medline Journal Info:
Nlm Unique ID:  101276222     Medline TA:  Adv Med Sci     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  143-5     Citation Subset:  IM    
Internal Medicine Department, Cardarelli Hospital, Napoli, Italy.
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MeSH Terms
Aged, 80 and over
Cholangiopancreatography, Endoscopic Retrograde
Hyperamylasemia / diagnosis*,  radiography,  ultrasonography
Magnetic Resonance Imaging
Middle Aged
Pancreatic Diseases / diagnosis*,  radiography,  ultrasonography
Retrospective Studies

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