| Chronic arsenic toxicity from Ayurvedic medicines. | |
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MedLine Citation:
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PMID: 18477160 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Ayurvedic medicines are known to contain arsenic and concentrations up to toxic levels have been reported in certain formulations. However, clinical disease due to arsenic containing ayurvedic medicines has rarely been reported. We seek to highlight the existence of toxic levels of arsenic in certain ayurvedic preparations that can produce serious systemic manifestations. METHODS: An 11-year-old girl developed manifestations of arsenical keratosis (punctuate palmoplantar keratoderma and leucomelanoderma) and non-cirrhotic portal hypertension, 6 months and 18 months respectively after intake of ayurvedic medications, prescribed for epilepsy. The eight ayurvedic preparations consumed by the patient and her serum levels were analyzed for arsenic content. RESULTS: Arsenic content of ayurvedic medicines ranged from 5 mg/L to 248 mg/L. The serum arsenic level was 202.20 microg/L (normal < 60 microg/L). Skin manifestations improved after the discontinuation of ayurvedic medications. CONCLUSIONS: Ayurvedic medications should be consumed under strict guidance and supervision of qualified practitioners to prevent such catastrophies. |
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Authors:
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Sujay Khandpur; Amit K Malhotra; Vidhyut Bhatia; Subandhu Gupta; Vinod K Sharma; Rakesh Mishra; Narendra K Arora |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: International journal of dermatology Volume: 47 ISSN: 1365-4632 ISO Abbreviation: Int. J. Dermatol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-14 Completed Date: 2008-06-25 Revised Date: 2009-03-05 |
Medline Journal Info:
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Nlm Unique ID: 0243704 Medline TA: Int J Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 618-21 Citation Subset: IM |
Affiliation:
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Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arsenic
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analysis* Arsenic Poisoning / etiology* Child Chronic Disease Epilepsy / drug therapy Female Humans Hypertension, Portal / chemically induced* India Keratoderma, Palmoplantar / chemically induced*, pathology Liver / pathology Medicine, Ayurvedic* Phytotherapy / adverse effects* Pigmentation Disorders / chemically induced*, pathology Plant Preparations / chemistry, poisoning* Skin / pathology |
| Chemical | |
Reg. No./Substance:
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0/Plant Preparations; 7440-38-2/Arsenic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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