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Chronic arsenic exposure and risk of infant mortality in two areas of Chile.
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MedLine Citation:
PMID:  10903622     Owner:  NLM     Status:  MEDLINE    
Chronic arsenic exposure has been associated with a range of neurologic, vascular, dermatologic, and carcinogenic effects. However, limited research has been directed at the association of arsenic exposure and human reproductive health outcomes. The principal aim of this study was to investigate the trends in infant mortality between two geographic locations in Chile: Antofagasta, which has a well-documented history of arsenic exposure from naturally contaminated water, and Valparaíso, a comparable low-exposure city. The arsenic concentration in Antofagasta's public drinking water supply rose substantially in 1958 with the introduction of a new water source, and remained elevated until 1970. We used a retrospective study design to examine time and location patterns in infant mortality between 1950 and 1996, using univariate statistics, graphical techniques, and Poisson regression analysis. Results of the study document the general declines in late fetal and infant mortality over the study period in both locations. The data also indicate an elevation of the late fetal, neonatal, and postneonatal mortality rates for Antofagasta, relative to Valparaíso, for specific time periods, which generally coincide with the period of highest arsenic concentration in the drinking water of Antofagasta. Poisson regression analysis yielded an elevated and significant association between arsenic exposure and late fetal mortality [rate ratio (RR) = 1.7; 95% confidence interval (CI), 1.5-1.9], neonatal mortality (RR = 1.53; CI, 1.4-1.7), and postneonatal mortality (RR = 1.26; CI, 1.2-1.3) after adjustment for location and calendar time. The findings from this investigation may support a role for arsenic exposure in increasing the risk of late fetal and infant mortality.
C Hopenhayn-Rich; S R Browning; I Hertz-Picciotto; C Ferreccio; C Peralta; H Gibb
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Environmental health perspectives     Volume:  108     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-10-04     Completed Date:  2000-10-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  667-73     Citation Subset:  IM    
Department of Preventive Medicine and Environmental Health, University of Kentucky, Lexington 40504, USA.
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MeSH Terms
Arsenic / adverse effects*
Chile / epidemiology
Environmental Exposure*
Environmental Pollutants / adverse effects*
Infant Mortality / trends*
Infant, Newborn
Retrospective Studies
Risk Assessment
Water Supply
Reg. No./Substance:
0/Environmental Pollutants; 7440-38-2/Arsenic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 7 Year: 2000
Volume: 108 Issue: 7
First Page: 667 Last Page: 673
ID: 1638185
PubMed Id: 10903622
Publisher Item Identifier: sc271_5_1835

Chronic arsenic exposure and risk of infant mortality in two areas of Chile.
C Hopenhayn-Rich
S R Browning
I Hertz-Picciotto
C Ferreccio
C Peralta
H Gibb
Department of Preventive Medicine and Environmental Health, University of Kentucky, Lexington 40504, USA.

Article Categories:
  • Research Article

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