| Chronic anterior thalamus stimulation for intractable epilepsy. | |
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MedLine Citation:
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PMID: 12060019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: A significant number of patients with epilepsy remain poorly controlled despite antiepileptic medication (AED) treatment and are not eligible for resective surgery. Novel therapeutic methods are required to decrease seizure burden in this population. Several observations have indicated that the anterior thalamic region plays an important role in the maintenance and propagation of seizures. We investigated neuromodulation of the anterior thalamus by using deep-brain stimulation (DBS) in patients with intractable seizures. METHODS: Five patients with medically refractory epilepsy underwent stereotactic placement of and received stimulation through bilateral DBS electrodes in the anterior thalamus. RESULTS: Treatment showed a statistically significant decrease in seizure frequency, with a mean reduction of 54% (mean follow-up, 15 months). Two of the patients had a seizure reduction of > or =75%. No adverse effects were observed after DBS electrode insertion or stimulation. Unexpectedly, the observed benefits did not differ between stimulation-on and stimulation-off periods. CONCLUSIONS: DBS of the anterior thalamus is a safe procedure and possibly effective in patients with medically resistant seizures. |
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Authors:
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Mojgan Hodaie; Richard A Wennberg; Jonathan O Dostrovsky; Andres M Lozano |
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Publication Detail:
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Type: Case Reports; Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Epilepsia Volume: 43 ISSN: 0013-9580 ISO Abbreviation: Epilepsia Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-06-12 Completed Date: 2002-07-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
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Languages: eng Pagination: 603-8 Citation Subset: IM |
Affiliation:
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Division of Neurosurgery, University of Toronto, ON, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain Mapping Electric Stimulation Therapy / methods* Electrodes, Implanted Epilepsy / therapy* Female Follow-Up Studies Functional Laterality / physiology Humans Male Middle Aged Prospective Studies Stereotyped Behavior Thalamus / physiology* Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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