Document Detail

Chronic anterior thalamus stimulation for intractable epilepsy.
MedLine Citation:
PMID:  12060019     Owner:  NLM     Status:  MEDLINE    
PURPOSE: A significant number of patients with epilepsy remain poorly controlled despite antiepileptic medication (AED) treatment and are not eligible for resective surgery. Novel therapeutic methods are required to decrease seizure burden in this population. Several observations have indicated that the anterior thalamic region plays an important role in the maintenance and propagation of seizures. We investigated neuromodulation of the anterior thalamus by using deep-brain stimulation (DBS) in patients with intractable seizures. METHODS: Five patients with medically refractory epilepsy underwent stereotactic placement of and received stimulation through bilateral DBS electrodes in the anterior thalamus. RESULTS: Treatment showed a statistically significant decrease in seizure frequency, with a mean reduction of 54% (mean follow-up, 15 months). Two of the patients had a seizure reduction of > or =75%. No adverse effects were observed after DBS electrode insertion or stimulation. Unexpectedly, the observed benefits did not differ between stimulation-on and stimulation-off periods. CONCLUSIONS: DBS of the anterior thalamus is a safe procedure and possibly effective in patients with medically resistant seizures.
Mojgan Hodaie; Richard A Wennberg; Jonathan O Dostrovsky; Andres M Lozano
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Publication Detail:
Type:  Case Reports; Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epilepsia     Volume:  43     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-12     Completed Date:  2002-07-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  603-8     Citation Subset:  IM    
Division of Neurosurgery, University of Toronto, ON, Canada.
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MeSH Terms
Brain Mapping
Electric Stimulation Therapy / methods*
Electrodes, Implanted
Epilepsy / therapy*
Follow-Up Studies
Functional Laterality / physiology
Middle Aged
Prospective Studies
Stereotyped Behavior
Thalamus / physiology*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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