Document Detail


Chronic anterior thalamus stimulation for intractable epilepsy.
MedLine Citation:
PMID:  12060019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: A significant number of patients with epilepsy remain poorly controlled despite antiepileptic medication (AED) treatment and are not eligible for resective surgery. Novel therapeutic methods are required to decrease seizure burden in this population. Several observations have indicated that the anterior thalamic region plays an important role in the maintenance and propagation of seizures. We investigated neuromodulation of the anterior thalamus by using deep-brain stimulation (DBS) in patients with intractable seizures. METHODS: Five patients with medically refractory epilepsy underwent stereotactic placement of and received stimulation through bilateral DBS electrodes in the anterior thalamus. RESULTS: Treatment showed a statistically significant decrease in seizure frequency, with a mean reduction of 54% (mean follow-up, 15 months). Two of the patients had a seizure reduction of > or =75%. No adverse effects were observed after DBS electrode insertion or stimulation. Unexpectedly, the observed benefits did not differ between stimulation-on and stimulation-off periods. CONCLUSIONS: DBS of the anterior thalamus is a safe procedure and possibly effective in patients with medically resistant seizures.
Authors:
Mojgan Hodaie; Richard A Wennberg; Jonathan O Dostrovsky; Andres M Lozano
Related Documents :
19162229 - Effectiveness and tolerability of rufinamide in children and adults with refractory epi...
8517559 - Clinical predictors of post-traumatic seizures in children with head trauma.
2929129 - Serum enzyme disturbances after tricyclic antidepressant overdose.
21038079 - Vagus nerve stimulation: effectiveness and tolerability in patients with epileptic ence...
17723289 - Young patients with focal seizures may have the primary motor area for the hand in the ...
10403209 - A particular type of epilepsy in children with congenital hemiparesis associated with u...
22652729 - Calcimimetics in peritoneal dialysis patients.
272799 - Rapid cytoreduction in acute leukemia. management of cerebral leukostasis by cell phere...
14665869 - Tumor marker levels in post-chemotherapy cystic masses: clinical implications for patie...
Publication Detail:
Type:  Case Reports; Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epilepsia     Volume:  43     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-12     Completed Date:  2002-07-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  603-8     Citation Subset:  IM    
Affiliation:
Division of Neurosurgery, University of Toronto, ON, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Brain Mapping
Electric Stimulation Therapy / methods*
Electrodes, Implanted
Epilepsy / therapy*
Female
Follow-Up Studies
Functional Laterality / physiology
Humans
Male
Middle Aged
Prospective Studies
Stereotyped Behavior
Thalamus / physiology*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Detection and localization of focal cortical dysplasia by voxel-based 3-D MRI analysis.
Next Document:  Different neurophysiologic patterns of myoclonus characterize Lennox-Gastaut syndrome and myoclonic ...