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Chronic anemia due to watermelon stomach.
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MedLine Citation:
PMID:  20220268     Owner:  NLM     Status:  MEDLINE    
Antral gastric vascular ectasia is a rare cause of chronic anemia. When encountered, the diagnosis is usually delayed. Endoscopic findings are well established, although radiologic findings are not. Patients respond well to surgery. Our case was of a 62-year-old female with chronic anemia who required multiple blood transfusions and iron replacement therapy, without significant response. Computed tomography revealed a focal thickening of the gastric antrum. Endoscopy showed vascular ectasia between the antrum and corpus. The patient underwent gastrectomy. We reviewed the literature on gastric angiodysplasia and have presented our unique tomography findings in this first report on a novel association between ectopic pancreas and gastric angiodysplasia.
Baris Yildiz; Cenk Sokmensuer; Volkan Kaynaroglu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of Saudi medicine     Volume:  30     ISSN:  0975-4466     ISO Abbreviation:  Ann Saudi Med     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-03-11     Completed Date:  2010-06-04     Revised Date:  2010-09-30    
Medline Journal Info:
Nlm Unique ID:  8507355     Medline TA:  Ann Saudi Med     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  156-8     Citation Subset:  IM    
Department of General Surgery, Hacettepe University, Sihhiye, Ankara, Turkey.
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MeSH Terms
Anemia / diagnosis,  etiology*,  surgery
Choristoma / complications
Chronic Disease
Gastric Antral Vascular Ectasia / complications*,  radiography,  surgery
Middle Aged
Pyloric Antrum / pathology
Stomach Diseases / complications
Time Factors
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Ann Saudi Med
Journal ID (publisher-id): ASM
ISSN: 0256-4947
ISSN: 0975-4466
Publisher: Medknow Publications, India
Article Information
? Annals of Saudi Medicine
Print publication date: Season: Mar?Apr Year: 2010
Volume: 30 Issue: 2
First Page: 156 Last Page: 158
ID: 2855069
Publisher Id: ASM-30-156
PubMed Id: 20220268
DOI: 10.4103/0256-4947.60524

Chronic anemia due to watermelon stomach
Baris Yildiza
Cenk Sokmensuera
Volkan Kaynaroglub
aFrom the Department of General Surgery, Hacettepe University, Ankara, Turkey
bFrom the Department of Pathology, Hacettepe University, Ankara, Turkey
Correspondence: Correspondence: Dr. Baris Yildiz ? Department of General Surgery, Hacettepe University, Sihhiye, Ankara 06810, Turkey ? T: +90-532-445-4655 Fax: +90-312-424-1520 ? ? Accepted for publication June 2009

Although the differential diagnosis of chronic anemia might seem straightforward, intriguing choices can be encountered during its evaluation. Finding the etiology of anemia can be challenging, especially in females and elderly patients. Evaluation starts with a basic physical examination, but may even require surgical exploration in difficult cases. The insidious nature of the chronic blood loss renders such patients symptomless for prolonged periods despite very low hemoglobin values. Rare disease associations and unusual clinical findings should be kept in mind for cases with obscure etiologies. We describe a rare cause of chronic anemia with a unique association.


A 62-year-old female patient presented to our outpatient clinic with fatigue. She had been followed for anemia, with changing hemoglobin values, between 7 and 11 g/dL (normal reference range, 12-18 g/dL), for over six years in different centers. An occult fecal blood test was positive and fecal parasite analysis was negative. She had received multiple tranfusions in the previous six years and had been started on oral iron replacement therapy before presenting to our clinic. Colonoscopy revealed normal findings. Two years previously she was diagnosed with antral vascular ectasia by endoscopy. Endoscopic cauterization of the bleeding foci had been performed twice.

At the latest presentation, a CT scan showed focal thickening of the gastric antrum (Figure 1). A repeat endoscopy revealed vascular ectasia between the antrum and corpus. Her hemoglobin level was 8.8 g/dL. The only serum biochemistry abnormality was a high indirect bilirubin of 1.55 (normal reference range, 0.10-1.20 mg/dL). Her physical examination was normal except for laparoscopic cholecystectomy incision scars.

Considering the intractable course of her disease, she underwent surgery. During the operation, the abdominal exploration was normal. After gastrotomy, columns of angiodysplasia were seen running from the antrum to the corpus (Figures 2 and 3). Hemigastrectomy and a Billroth 2 procedure were performed. The postoperative course of the patient was uneventful. She was discharged with normal oral intake.

The pathology report showed mucosal and submucosal malformation of the dilated vascular structures, which were compatible with angiodysplasia (Figures 4 and 5). A focus on ectopic pancreas was seen on the antrum.


Common causes of upper gastrointestinal hemorrhage include peptic ulcer disease, esophageal varices, gastritis, esophagitis, and Mallory-Weiss tears. One of the unusual causes is gastric antral angiodysplasia which results in major chronic gastrointestinal hemorrhage. Apart from anemia, gastric outlet obstruction is also reported in these patients.1 The pathognomonic histological features include foveolar hyperplasia, vascular ectasia with clots, and fibromuscular spindle cell hyperplasia of the lamina propria.2, 3 Chronic unexplained anemia resulting from bleeding of abnormal gastric vessels is a well recognized phenomenon but the condition is poorly documented and its etiology and pathogenesis are unclear.4?6

This syndrome was first recognized endoscopically by Wheeler et al. in 1979, but it was Jabbari et al. who first described three patients of their own and identified four cases from published reports.5, 7 The etiology of this condition remains unknown. These lesions can be seen in cirrhosis, in up to 30% of the patients, in two forms, as portal hypertensive gastropathy and gastric antral vascular ectasia, which are two seperate entities based on endoscopic and histolpathological findings.8 In this setting, bleeding is usually slow and insidious and rarely massive and life threatening.9?11

In the absence of cirrhosis, gastric antral vascular ectasia is a distinct clinicopathological entity. The most widely accepted theory for the etiology focuses on the recurrent episodes of antral mucosal prolapse or an intussusception into the pylorus that would lead to chronic trauma and to consequent fibromuscular hyperplasia of the antral wall. Vasoactive substances as well as increased gastrin levels may play an important role in the pathophysiology, promoting vasodilatation and antral motility.12 The resemblance of the histological findings to those of prolapse of the rectal mucosa, and those seen at stomal sites, support this theory.3

In the diagnosis, endoscopic findings are crucial and columns of dilated ectatic vessels on the summits of prominent antral rugal folds are characteristic. These appearances, however, can easily be misinterpreted as moderate-to-severe gastritis.13

Although recommended by most authorities, radiological investigations, including barium meal and mesenteric angiography, often fail to make the diagnosis, and identification of the cause of blood loss is usually delayed for many years.14, 15 These patients characteristically respond well to antrectomy and Bilroth anastomosis. Long-term corticosteroids and heat probe therapy have been reported as a safe options in older, medically unfit patients, while others have advocated endoscopic laser treatment.16, 17 Our case shows once again that in the workup for differential diagnosis of chronic anemia, gastric angiodysplasia should be investigated. Although there are not many reports on the characteristic CT findings in this entity, our case supports the CT findings of other authors. We feel that this should prompt a planned radiological research to identify characteristic appearances on CT, which could be used for patients not suitable for endoscopy. One other interesting finding was ectopic pancreas, in our pathology specimen. There are no other reports in the literature on this association.

1. Tuveri M,Borsezio V,Gabbas A,Mura G. Gastric antral vascular ectasia: An unusual cause of gastric outlet obstruction: Report of a caseSurg TodayYear: 200737503517522771
2. Kruger R,Ryan ME,Dickson KB,Nunez JF. Diffuse vascular ectasia of the gastric antrumAm J GastroenterolYear: 19878242163578221
3. Suit PF,Petras RE,Bauer TW,Petrini JL Jr. Gastric antral vascular ectasia: A histologic and morphometnic study of ?the watermelon stomach?Am J Surg PatholYear: 198711750753499091
4. Pastershank SP,Chappell EW,Buchan DJ,Chow KC. Arterio-venous malformation of the stomachCan Med Assoc JYear: 19741105784809447
5. Wheeler MH,Smith PM,Cotton PB,Evans DM,Lawrie BW. Abnormal blood vessels in the gastric antrumDig Dis SciYear: 1979241558311727
6. Lewis TD,Laufer I,Goodacre RL. Arterio-venous malformation of the stomach. Radiologic and endoscopic featuresAm J Dig DisYear: 19782346771677099
7. Jabbari M,Cherry R,Lough JO,Daly DS,Kinnear DC,Goresky CA. Gastric antral vascular ectasia: the watermelon stomachGastroenterologyYear: 1984371165706332757
8. Payen JL,Cal?s P,Voigt JJ,Barbe S,Pilette C,Dubuisson L,et al. Severe portal hypertensive gastropathy and antral vascular ectasia are distinct entities in patients with cirrhosisGastroenterologyYear: 1995108138447806035
9. Payen JL,Cal?s P,Voigt JJ,Barbe S,Pilette C,Dubuisson L,et al. Severe portal hypertensive gastropathy and antral vascular ectasia are distinct entities in patients with cirrhosisGastroenterologyYear: 1995108138447806035
10. Viggiano TR,Gostout CJ. Portal hypertensive intestinal vasculopathy: A review of the clinical, endoscopic and histopathologic featuresAm J GastroenterolYear: 199287944541642217
11. Spina GP,Arcidiacono R,Bosch J,Pagliaro L,Burroughs AK,Santambrogio R,et al. Gastric endoscopic features in portal hypertension: Final report of a consensus conference, Milan, Italy, September 19, 1992J HepatolYear: 19942146177836719
12. Novitsky YW,Kercher KW,Czerniach DR,Litwin DE. Watermelon stomach: Pathophysiology, diagnosis and managementJ Gastrointest SurgYear: 200376526112850679
13. Yamada M,Nishimura D,Hoshino H,Katada N,Sano H,Kato K. Gastric antral vascular ectasia successfully treated by endoscopic electrocoagulationJ GastroenterolYear: 19983354699719240
14. Calam J,Walker RJ. Antral vascular lesion, achlorhydria and chronic blood loss. Response to steroidsDig Dis SciYear: 19802523696966212
15. Kern SE,Ravich WJ. Gastric antral vascular ectasia ?watermelon stomach? radiologic findingsRadiologyYear: 199117851781987618
16. Gouldesbrough DR,Pell AC. Gastric antral vascular ectasia: A problem of recognition and diagnosisGutYear: 19913295451885080
17. Potamiano S,Carter CR,Anderson JR. Endoscopic laser treatment of diffuse gastric antral vascular ectasiaGutYear: 19943546138174981


[Figure ID: F0001]
Figure 1 

CT scan showing focal thickening of the gastric antrum.

[Figure ID: F0002]
Figure 2 

Columns of angiodysplasia.

[Figure ID: F0003]
Figure 3 

Close-up view of the angiodysplasia columns with antrum everted.

[Figure ID: F0004]
Figure 4 

Submucosal abnormal vascular dilatation and structures that have penetrated into the mucosa, (hematoxylin and eosin, ?40).

[Figure ID: F0005]
Figure 5 

The lesion is well demarcated from the surrounding fibroconnective tissue, (hematoxylin and eosin, ?40).

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