Document Detail

Chronic alcohol consumption intensifies caerulein-induced acute pancreatitis in the rat.
MedLine Citation:
PMID:  1527448     Owner:  NLM     Status:  MEDLINE    
Rats were chronically fed either an ethanol-containing diet (36% of total calories derived from alcohol) or a pair-fed, control diet (no alcohol) for 8 wk, and acute pancreatitis (AP) was subsequently induced by a 3-h i.v. infusion of caerulein (CR) at a dose of 5 micrograms/kg/hr. CR-induced AP in control rats (no alcohol) was characterized by a significant elevation in serum lipase content, pancreatic interstitial edema, infrequent occurrences of karyorrhexis, and the appearance of vacuoles in acinar cells. Chronic feeding of the ethanol diet followed by treatment with CR resulted in increases in serum lipase content, interstitial edema, karyorrhexis, and acinar vacuolization that were significantly greater than that seen in rats fed the control diet and treated with CR. It is concluded that chronic ethanol intake in the rat intensifies AP that is subsequently induced by CR.
M G Quon; M Kugelmas; J R Wisner; P Chandrasoma; J E Valenzuela
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of pancreatology : official journal of the International Association of Pancreatology     Volume:  12     ISSN:  0169-4197     ISO Abbreviation:  Int. J. Pancreatol.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-10-22     Completed Date:  1992-10-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8703511     Medline TA:  Int J Pancreatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  31-9     Citation Subset:  IM    
Department of Medicine, University of Southern California School of Medicine, Los Angeles.
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MeSH Terms
Acute Disease
Alcoholism / complications*
Disease Models, Animal*
Edema / pathology
Lipase / blood
Lysosomes / pathology
Pancreas / pathology
Pancreatitis / chemically induced*,  enzymology,  etiology,  pathology
Rats, Inbred Strains
Vacuoles / pathology
Grant Support
R01-M07676-01A1//PHS HHS
Reg. No./Substance:
17650-98-5/Caerulein; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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