| Chronic alcohol consumption enhances sepsis-induced cardiac dysfunction. | |
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MedLine Citation:
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PMID: 2058723 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic alcoholism causes a cardiac contractile dysfunction which, in rats, may occur after 6 mo to 1 yr of alcohol consumption. Sepsis, on a more acute basis, can also induce intrinsic cardiac dysfunction. We tested the hypothesis that 2 mo of chronic alcohol feeding, while not directly causing overt depression of the myocardium, might sensitize the heart to a known cardiac stress, i.e., sepsis. We proposed that sepsis, induced in an alcoholic animal, would cause a more severe myocardial depression than in a nonalcoholic rat. Thus rats were fed a liquid diet with 36% of the total calories as alcohol for 8-10 wk and were then anesthetized and received an injection of live Escherichia coli (approximately 10(10) E. coli) through a dorsal subcutaneous catheter followed by a second dose approximately 5 h later. The following day, hearts were removed and, using the isolated working heart preparation, intrinsic contractile performance was assessed by generating ventricular function curves. Four groups of animals were studied. Hearts from the nonalcoholic-nonseptic group and the alcoholic-nonseptic group showed identical cardiac work (cardiac output x peak systolic pressure at the highest preload was 6,113 +/- 324 and 5,955 +/- 406 ml.min-1.mmHg-1, respectively). Work in the nonalcoholic-septic and the alcoholic-septic groups was decreased by 30 and 50%, respectively (4,806 +/- 478 vs. 2,917 +/- 435 ml.min-1.mmHg-1 at the highest preload). Thus 2 mo chronic alcohol consumption caused no overt cardiac dysfunction by itself but did exacerbate the myocardial injury induced by sepsis. |
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Authors:
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K H McDonough; J J Henry |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 260 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1991 Jun |
Date Detail:
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Created Date: 1991-08-01 Completed Date: 1991-08-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H1857-63 Citation Subset: IM |
Affiliation:
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Department of Physiology, Louisiana State University Medical Center, New Orleans 70112. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcoholism
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physiopathology* Animals Blood Pressure Cardiac Output Coronary Circulation Escherichia coli / isolation & purification Heart Diseases / microbiology, pathology, physiopathology* Heart Rate Hemodynamics* Male Myocardium / metabolism, pathology Rats Rats, Inbred Strains Sepsis / microbiology, physiopathology* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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AA07747/AA/NIAAA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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