Document Detail

Chronic airway disease: deteriorating pulmonary function in sheep associated with repeated challenges of house dust mite.
MedLine Citation:
PMID:  17060175     Owner:  NLM     Status:  MEDLINE    
The aim of this work was to characterize lung function and cellular responses in a large animal model for chronic asthma. All sheep were sensitized to house dust mite (HDM) by subcutaneous injection of HDM before lung challenges. Groups of sheep were given weekly lung challenges with either HDM (n = 12) or saline (control, n = 5) for 3 months. Post challenge, there were significant increases in lung resistance in 7 out of 12 HDM-challenged sheep, compared to control sheep. In HDM-responding sheep, there was a progressive increase in the magnitude of HDM-induced resistance throughout the trial. All HDM-challenged sheep developed BAL eosinophilia and bronchial hyperresponsiveness. In conclusion, sheep chronically challenged intralung with HDM consistently develop airway hyperresponsiveness and eosinophilia, whereas allergen-specific bronchoconstriction is observed in just over half of these sheep.
Emmanuel Koumoundouros; Robert J Bischof; Els N Meeusen; Iven M Y Mareels; Kenneth J Snibson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental lung research     Volume:  32     ISSN:  0190-2148     ISO Abbreviation:  Exp. Lung Res.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-10-24     Completed Date:  2006-11-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004944     Medline TA:  Exp Lung Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  321-30     Citation Subset:  IM    
Centre for Animal Biotechnology, Department of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia.
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MeSH Terms
Airway Resistance
Antigens, Dermatophagoides / adverse effects*,  pharmacology
Asthma / etiology*,  pathology,  physiopathology*
Bronchial Hyperreactivity / etiology,  pathology,  physiopathology
Bronchoconstriction / drug effects,  physiology
Chronic Disease
Disease Models, Animal
Inhalation Exposure*
Lung / drug effects,  parasitology,  pathology,  physiopathology*
Pulmonary Eosinophilia / etiology,  pathology,  physiopathology
Pyroglyphidae / pathogenicity*
Respiratory Hypersensitivity / etiology,  pathology,  physiopathology
Reg. No./Substance:
0/Antigens, Dermatophagoides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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