| Chronic agomelatine treatment corrects the abnormalities in the circadian rhythm of motor activity and sleep/wake cycle induced by prenatal restraint stress in adult rats. | |
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MedLine Citation:
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PMID: 22310059 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Agomelatine is a novel antidepressant acting as an MT1/MT2 melatonin receptor agonist/5-HT2C serotonin receptor antagonist. Because of its peculiar pharmacological profile, this drug caters the potential to correct the abnormalities of circadian rhythms associated with mood disorders, including abnormalities of the sleep/wake cycle. Here, we examined the effect of chronic agomelatine treatment on sleep architecture and circadian rhythms of motor activity using the rat model of prenatal restraint stress (PRS) as a putative 'aetiological' model of depression. PRS was delivered to the mothers during the last 10 d of pregnancy. The adult progeny ('PRS rats') showed a reduced duration of slow wave sleep, an increased duration of rapid eye movement (REM) sleep, an increased number of REM sleep events and an increase in motor activity before the beginning of the dark phase of the light/dark cycle. In addition, adult PRS rats showed an increased expression of the transcript of the primary response gene, c-Fos, in the hippocampus just prior to the beginning of the dark phase. All these changes were reversed by a chronic oral treatment with agomelatine (2000 ppm in the diet). The effect of agomelatine on sleep was largely attenuated by treatment with the MT1/MT2 melatonin receptor antagonist, S22153, which caused PRS-like sleep disturbances on its own. These data provide the first evidence that agomelatine corrects sleep architecture and restores circadian homeostasis in a preclinical model of depression and supports the value of agomelatine as a novel antidepressant that resynchronizes circadian rhythms under pathological conditions. |
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Authors:
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Jerome Mairesse; Viviana Silletti; Charlotte Laloux; Anna Rita Zuena; Angela Giovine; Michol Consolazione; Gilles van Camp; Marithe Malagodi; Silvana Gaetani; Silvia Cianci; Assia Catalani; Gioacchino Mennuni; Alessandro Mazzetta; Olivier van Reeth; Cecilia Gabriel; Elisabeth Mocaër; Ferdinando Nicoletti; Sara Morley-Fletcher; Stefania Maccari |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-6 |
Journal Detail:
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Title: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) Volume: - ISSN: 1469-5111 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815893 Medline TA: Int J Neuropsychopharmacol Country: - |
Other Details:
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Languages: ENG Pagination: 1-16 Citation Subset: - |
Affiliation:
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Neuroplasticity Team UMR 8576 CNRS 'Structural and Functional Glycobiology Unit', University Lille North of France, Villeneuve d'Ascq, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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