Document Detail


Chronic adrenergic receptor blockade does not prevent hyperinsulinemia-induced hypertension in rats.
MedLine Citation:
PMID:  8972890     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increased adrenergic activity has been suggested to mediate the hypertension associated with hyperinsulinemia. This study tested whether combined alpha1- and beta-adrenergic receptor blockade would prevent insulin-induced hypertension when euglycemia was maintained by continuous intravenous glucose infusion. Sprague-Dawley rats (n = 16) were instrumented with artery and vein catheters and placed in metabolic cages. Propranolol and prazosin (10 mg/kg/day each) were infused continuously intravenously in 9 rats and 7 other rats received vehicle. Mean arterial pressure (MAP) and heart rate (HR) were measured 24 h per day using computerized methods. After a control period, a 7-day intravenous infusion of insulin (1.5 microU/kg/min) was begun and glucose was coadministered intravenously at 23 mg/kg/min to prevent hypoglycemia. The MAP averaged 93 +/- 1 mm Hg in the blockade rats during the control period, which was significantly lower than the 98 +/- 1 mm Hg in the normal rats. During insulin infusion, MAP increased similarly in both groups, with a 10 +/- 2 mm Hg and 11 +/- 1 mm Hg increase in normal and blockade rats, respectively, by day 7. The HR also increased in both groups: from 417 +/- 8 beats/ min to 426 +/- 13 beats/min (P = NS) in normal rats and from 379 +/- 10 beats/min to 419 +/- 10 beats/min (P < .05) in blockade rats. Control sodium excretion averaged 2.5 +/- 0.1 mEq/day in both groups and no significant change in sodium balance was measured in either group. All variables returned toward control after stopping insulin. These results suggest that increased adrenergic activity is not required for chronic hyperinsulinemia to raise blood pressure in rats.
Authors:
H L Keen; M W Brands; M Alonso-Galicia; J E Hall
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hypertension     Volume:  9     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-04-08     Completed Date:  1997-04-08     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1192-9     Citation Subset:  IM    
Affiliation:
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Antagonists / administration & dosage,  pharmacology
Adrenergic beta-Antagonists / administration & dosage,  pharmacology
Animals
Blood Glucose / metabolism
Blood Pressure / drug effects
Drug Therapy, Combination
Glomerular Filtration Rate
Glucose / administration & dosage
Hyperinsulinism / chemically induced,  complications*,  metabolism
Hypertension / etiology*,  prevention & control*
Hypoglycemia / blood,  complications,  prevention & control
Insulin / administration & dosage,  pharmacokinetics,  toxicity
Male
Potassium / urine
Prazosin / administration & dosage,  pharmacology
Propranolol / administration & dosage,  pharmacology
Radioimmunoassay
Rats
Rats, Sprague-Dawley
Receptors, Adrenergic / drug effects*
Sodium / urine
Grant Support
ID/Acronym/Agency:
HL-23502/HL/NHLBI NIH HHS; HL-39399/HL/NHLBI NIH HHS; HL-51971/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Blood Glucose; 0/Receptors, Adrenergic; 11061-68-0/Insulin; 19216-56-9/Prazosin; 50-99-7/Glucose; 525-66-6/Propranolol; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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