| Chronic administration of chenodeoxycholic acid increases cholesterol saturation in bile in the dog. | |
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MedLine Citation:
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PMID: 110595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Six dogs were given chenodeoxycholic acid, 200 mg/day for 15 days; gallbladder and hepatic bile samples were taken and biliary bile acids, phospholipids and cholesterol were compared to those of fourteen control dogs. It was found that: (1) the cholesterol saturation index of gallbladder bile was higher in treated dogs (0.12 +/- 0.06; m +/- SD) than in controls (0.07 +/- 0.01; P less than 0.05); the proportion of chenodeoxycholic acid in gallbladder bile was higher in treated dogs (27.8 +/- 12.5%) than in controls (4.5 +/- 1.9%; P less than 0.01); (2) in hepatic bile, the saturation index and proportion of chenodeoxycholic acid were significantly higher in treated dogs (respectively 0.13 +/- 0.03 and 21.6 +/- 8.8%) than in control dogs (respectively 0.07 +/- 0.01; P less than 0.01 and 4.6 +/- 2.2%; P less than 0.01). In the dog, chronic administration of chenodeoxycholic acid increases cholesterol saturation in bile. It is concluded that the difference of effect of chenodeoxycholic acid in man and in the dog is not related to the duration of administration, but to a species difference. |
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Authors:
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R E Poupon; R Y Poupon; M Duval; L Le Quernec; S Erlinger |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of clinical investigation Volume: 9 ISSN: 0014-2972 ISO Abbreviation: Eur. J. Clin. Invest. Publication Date: 1979 Feb |
Date Detail:
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Created Date: 1979-09-17 Completed Date: 1979-09-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0245331 Medline TA: Eur J Clin Invest Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 103-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Bile / metabolism* Chenodeoxycholic Acid / pharmacology* Cholesterol / metabolism* Dogs Time Factors |
| Chemical | |
Reg. No./Substance:
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474-25-9/Chenodeoxycholic Acid; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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