| Chronic administration of the antiretroviral nevirapine increases body weight, food, and water intake in albino Wistar rats. | |
| | |
MedLine Citation:
|
PMID: 22944657 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Abstract Background: Nevirapine (NVP) is an antiretroviral medication that prevents human immunodeficiency virus (HIV) cells from multiplying in the blood. This study was undertaken to investigate the effect of chronic administration of NVP on body weight, food, and water intake using apparently healthy albino Wistar rats. Methods: Twenty adult albino Wistar rats (50-125 g body weight) were used for the study. Rats in the control group (n=10) were fed normal rodent chow, whereas the NVP group (n=10) were fed by gavage NVP (0.4 mg/kg body weight) two times daily (07.00 h and 18.00 h) in addition to normal rodent chow for 12 weeks. All animals were allowed free access to clean drinking water. Results: Results showed that the mean daily food and water intake in the NVP group were significantly higher (p<0.001) when compared with the control group, respectively. The mean change in body weight in the NVP group was significantly higher (p<0.001) than the control group. Conclusions: These results suggest that chronic administration of NVP may increase body weight in rats, probably due to its stimulatory effects on food and water intake. |
| | |
Authors:
|
Elizabeth Bassey Umoren; Agona Odeh Obembe; Eme Effiom Osim |
Related Documents
:
|
6061887 - Potamotrygon spp.: elasmobranchs with low urea content. 23678817 - Potential applications for annona squamosa leaf extract in the treatment and prevention... 21550357 - Food anticipation and subsequent food withdrawal increase serum cortisol in healthy men. 20593177 - Hunting, livelihoods and declining wildlife in the hponkanrazi wildlife sanctuary, nort... 3011357 - Food applications and the toxicological and nutritional implications of amorphous silic... 2744927 - Nationwide survey on nutritional habits in elite athletes. part i. energy, carbohydrate... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of basic and clinical physiology and pharmacology Volume: 23 ISSN: 0792-6855 ISO Abbreviation: J Basic Clin Physiol Pharmacol Publication Date: 2012 |
Date Detail:
|
Created Date: 2012-09-04 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9101750 Medline TA: J Basic Clin Physiol Pharmacol Country: Germany |
Other Details:
|
Languages: eng Pagination: 89-92 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of tenofovir, an antiretroviral drug, on hepatic and renal functional indices of Wistar rats:...
Next Document: Mitophagy: mechanisms, pathophysiological roles, and analysis.