| Chronic administration of aldosterone depresses baroreceptor reflex function in the dog. | |
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MedLine Citation:
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PMID: 7960015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a previous study it was shown that acute perfusion of aldosterone into the isolated carotid sinus decreased baroreceptor activity. The aim of the present study was to determine whether chronic, systemic administration of aldosterone also depresses baroreflex function. In six conscious dogs, the baroreflex was determined before and 10 days after an osmotic minipump containing aldosterone (100 micrograms/kg in 2 mL) was implanted. The slope of the relation between systolic arterial pressure and heart rate was significantly blunted after aldosterone administration (9.1 +/- 0.7 versus 13.3 +/- 1.2 for nitroglycerin, P < .01; 23.4 +/- 5.0 versus 40.1 +/- 5.0 for phenylephrine, P < .01). Baroreflex slopes did not change in a sham group (minipump with saline) and an aldosterone plus spironolactone (600 mg/d) group. Plasma aldosterone levels were significantly elevated after the aldosterone minipump was implanted (443 +/- 72 versus 37 +/- 11 pg/mL, P < .001). Mean arterial pressure was not significantly increased after aldosterone (106.5 +/- 3.8 versus 100.4 +/- 2.6 mm Hg, P = .2). On the 10th day after aldosterone or saline infusion, an acute experiment was carried out. Single baroreceptor fibers were recorded from the carotid sinus nerve. Compared with the sham group, the threshold was significantly elevated in the aldosterone group (111.3 +/- 2.1 versus 85.8 +/- 2.8 mm Hg), and the peak discharge rate was markedly decreased (32.5 +/- 1.5 versus 54.7 +/- 2.5 spikes per second, P < .01). The depressed baroreceptor function could be partially restored after a bolus injection of the Na+,K(+)-ATPase inhibitor ouabain (5 micrograms/kg i.v.).(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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W Wang |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension Volume: 24 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1994-12-02 Completed Date: 1994-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 571-5 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, University of Nebraska, College of Medicine, Omaha 68198-4575. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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administration & dosage,
pharmacology* Animals Baroreflex / drug effects* Blood Pressure / drug effects* Catheters, Indwelling Dogs Female Heart Rate / drug effects* Infusions, Parenteral Male Nitroglycerin / pharmacology Ouabain / pharmacology Phenylephrine / pharmacology Pressoreceptors / drug effects, physiology Reference Values Regression Analysis Spironolactone / pharmacology Time Factors |
| Chemical | |
Reg. No./Substance:
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52-01-7/Spironolactone; 52-39-1/Aldosterone; 55-63-0/Nitroglycerin; 59-42-7/Phenylephrine; 630-60-4/Ouabain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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