Document Detail

Chronic active Epstein-Barr virus infection with giant coronary aneurysms.
MedLine Citation:
PMID:  8659448     Owner:  NLM     Status:  MEDLINE    
Chronic active Epstein-Barr virus infection (CAEBV) is a nonfamilial syndrome that shows a specific immunodeficiency for the Epstein-Barr virus (EBV). Prolonged fever, hepatosplenomegaly, lymphadenopathy, and liver dysfunction were seen in CAEBV, but cardiac complications are rare. An autopsy case of CAEBV with giant coronary aneurysms and aortic aneurysms is reported. The patient was a 5-year-old Japanese girl. At autopsy, the heart weighed 110 g, and bilateral coronary aneurysms were found. Microscopic studies revealed lymphoid vasculitis of coronary arteries, coronary venules, and aortic arteries. Immunohistochemically, infiltrating small lymphocytes were positive for CD3, CD45RO(UCHL-1), CD43(DF-T1). The presence of EBV in most of these T lymphocytes was proven by in situ hybridization using an EBV-encoded RNA-1 (EBER1) probe. To the best of the author's knowledge, pathology of aneurysms caused by lymphoid vasculitis in CAEBV has not been reported until now.
A Nakagawa; M Ito; T Iwaki; Y Yatabe; J Asai; K Hayashi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  105     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-07-29     Completed Date:  1996-07-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  733-6     Citation Subset:  AIM; IM; X    
Department of Pathology, Nagoya University Hospital, Japan.
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MeSH Terms
Child, Preschool
Coronary Aneurysm / etiology,  pathology*,  virology
Fatal Outcome
Hepatitis, Chronic / pathology*
Herpesviridae Infections / pathology*
Herpesvirus 4, Human*
Tumor Virus Infections / pathology*

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