Document Detail

Chronic Urinary Retention Could Decrease the Number of Suburothelial Myofibroblasts in the Rat Bladder.
MedLine Citation:
PMID:  24643089     Owner:  NLM     Status:  Publisher    
Aims: To demonstrate changes in the number of suburothelial myofibroblasts in the rat bladder due to chronic urinary retention (CUR). Methods: Bladder specimens were obtained from 12-week-old Wistar female rats that were divided into two groups: a CUR group and a sham-operated group. In the CUR rats, the urethra was intubated with a polyethylene catheter, and a double 4-0 silk ligature was placed around the proximal urethra, after which the catheter was removed. After 8 weeks, the cystometric findings and immunohistochemical staining of the suburothelial myofibroblasts were compared between the groups. Results: The bladder weight of the control rats was 0.20 ± 0.01 g and that of CUR rats 1.6 ± 0.4 g. The bladder capacity of the control rats was 0.5 ± 0.3 ml and that of the CUR rats 12.9 ± 3.1 ml. The number of suburothelial myofibroblasts of the control rats was 417 ± 123 and that of the CUR rats 44 ± 42. The number of suburothelial myofibroblasts in the CUR rats was significantly less than that observed in the sham-operated rats (p < 0.01). Conclusions: In this study, we demonstrated that mechanical stress over a long period on the bladder wall can decrease the number of suburothelial myofibroblasts. The reduced expression of suburothelial myofibroblasts may be related to prolongation of the micturition interval by CUR. © 2014 S. Karger AG, Basel.
Shohei Tobu; Mitsuru Noguchi; Ken-Ichi Mori; Manabu Matsuo; Jiro Uozumi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-15
Journal Detail:
Title:  Urologia internationalis     Volume:  -     ISSN:  1423-0399     ISO Abbreviation:  Urol. Int.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417373     Medline TA:  Urol Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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