Document Detail

Chronic uremia stimulates LDL carbamylation and atherosclerosis.
MedLine Citation:
PMID:  20947625     Owner:  NLM     Status:  MEDLINE    
Carbamylated LDL (cLDL) is a potential atherogenic factor in chronic kidney disease (CKD). However, whether elevated plasma cLDL associates with atherosclerosis in vivo is unknown. Here, we induced CKD surgically in apolipoprotein E-deficient (ApoE(-/-)) mice fed a high-fat diet to promote the development of atherosclerosis. These mice had two- to threefold higher plasma levels of both oxidized LDL (oxLDL) and cLDL compared with control mice. Oral administration of urea increased cLDL approximately eightfold in ApoE(-/-) mice subjected to unilateral nephrectomy and a high-fat diet, but oxLDL did not rise. Regardless of the model, the uremic mice with high plasma cLDL had more severe atherosclerosis as measured by intravital ultrasound echography and en face aortic staining of lipid deposits. Furthermore, cLDL accumulated in the aortic wall and colocalized with ICAM-1 and macrophage infiltration. In summary, these data demonstrate that elevated plasma cLDL may represent an independent risk factor for uremia-induced atherosclerosis.
Eugene O Apostolov; Debarti Ray; Alena V Savenka; Sudhir V Shah; Alexei G Basnakian
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-10-14
Journal Detail:
Title:  Journal of the American Society of Nephrology : JASN     Volume:  21     ISSN:  1533-3450     ISO Abbreviation:  J. Am. Soc. Nephrol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-01     Completed Date:  2010-11-22     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9013836     Medline TA:  J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1852-7     Citation Subset:  IM    
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
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MeSH Terms
Apolipoproteins E / deficiency,  genetics
Atherosclerosis / blood*,  chemically induced,  epidemiology*
Chronic Disease
Dietary Fats / adverse effects
Disease Models, Animal
Intercellular Adhesion Molecule-1 / blood
Kidney Diseases / blood,  complications*,  etiology
Lipoproteins, LDL / blood*
Mice, Inbred C57BL
Mice, Knockout
Nephrectomy / adverse effects
Risk Factors
Urea / adverse effects
Uremia / blood,  chemically induced,  complications*
Grant Support
Reg. No./Substance:
0/Apolipoproteins E; 0/Dietary Fats; 0/Lipoproteins, LDL; 0/carbamyl-LDL; 0/oxidized low density lipoprotein; 126547-89-5/Intercellular Adhesion Molecule-1; 57-13-6/Urea

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