| Chronic uremia stimulates LDL carbamylation and atherosclerosis. | |
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MedLine Citation:
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PMID: 20947625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carbamylated LDL (cLDL) is a potential atherogenic factor in chronic kidney disease (CKD). However, whether elevated plasma cLDL associates with atherosclerosis in vivo is unknown. Here, we induced CKD surgically in apolipoprotein E-deficient (ApoE(-/-)) mice fed a high-fat diet to promote the development of atherosclerosis. These mice had two- to threefold higher plasma levels of both oxidized LDL (oxLDL) and cLDL compared with control mice. Oral administration of urea increased cLDL approximately eightfold in ApoE(-/-) mice subjected to unilateral nephrectomy and a high-fat diet, but oxLDL did not rise. Regardless of the model, the uremic mice with high plasma cLDL had more severe atherosclerosis as measured by intravital ultrasound echography and en face aortic staining of lipid deposits. Furthermore, cLDL accumulated in the aortic wall and colocalized with ICAM-1 and macrophage infiltration. In summary, these data demonstrate that elevated plasma cLDL may represent an independent risk factor for uremia-induced atherosclerosis. |
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Authors:
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Eugene O Apostolov; Debarti Ray; Alena V Savenka; Sudhir V Shah; Alexei G Basnakian |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-10-14 |
Journal Detail:
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Title: Journal of the American Society of Nephrology : JASN Volume: 21 ISSN: 1533-3450 ISO Abbreviation: J. Am. Soc. Nephrol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2010-11-22 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 9013836 Medline TA: J Am Soc Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 1852-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. apostolovyevgeniyo@uams.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apolipoproteins E / deficiency, genetics Atherosclerosis / blood*, chemically induced, epidemiology* Chronic Disease Dietary Fats / adverse effects Disease Models, Animal Intercellular Adhesion Molecule-1 / blood Kidney Diseases / blood, complications*, etiology Lipoproteins, LDL / blood* Male Mice Mice, Inbred C57BL Mice, Knockout Nephrectomy / adverse effects Risk Factors Urea / adverse effects Uremia / blood, chemically induced, complications* |
| Grant Support | |
ID/Acronym/Agency:
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1R21HL087405/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 0/Dietary Fats; 0/Lipoproteins, LDL; 0/carbamyl-LDL; 0/oxidized low density lipoprotein; 126547-89-5/Intercellular Adhesion Molecule-1; 57-13-6/Urea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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