Document Detail


Chronic stress-induced changes in pro-inflammatory cytokines and spinal glia markers in the rat: a time course study.
MedLine Citation:
PMID:  23051934     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: Spinal glia activation has been proposed as one mechanism underlying visceral hyperalgesia in a rodent model of chronic stress. In order to assess the possible role of changes in circulating cytokines and in blood-spinal cord barrier (BSCB) permeability in spinal glia activation, we studied the time course of peripheral and spinal pro-inflammatory cytokines and of spinal and satellite glia markers in response to repeated water avoidance (WA) stress.
METHODS: Spinal cords and dorsal root ganglion cells (DRGs) were collected from control rats, rats exposed to 1-hour WA, or 1-hour WA daily for 5 days or 1-hour WA daily for 10 days.
RESULTS: We demonstrated a time-dependent change in circulating IL-1β and spinal IL-1β, IL-6 and TNF-α in stressed animals compared with controls. We found altered expression of the astrocyte markers GFAP and Connexin 43 in spinal and DRG samples at different time points. Finally, WA was associated with increased BSCB permeability.
CONCLUSIONS: These findings confirm the concept that both peripheral and spinal immune markers are altered after chronic WA and suggest a possible link between stress-induced increase of peripheral pro-inflammatory cytokines, changes in satellite glial cells, increase in BSCB permeability and increase in spinal pro-inflammatory mediators suggesting glia activation.
Authors:
Viktoriya Golovatscka; Helena Ennes; Emeran A Mayer; Sylvie Bradesi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-06
Journal Detail:
Title:  Neuroimmunomodulation     Volume:  19     ISSN:  1423-0216     ISO Abbreviation:  Neuroimmunomodulation     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-30     Completed Date:  2013-08-22     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  9422763     Medline TA:  Neuroimmunomodulation     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  367-76     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
Oppenheimer Family Center for Neurobiology of Stress, Division of Digestive Diseases, UCLA David Geffen School of Medicine, Los Angeles, CA 90095-7378, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Avoidance Learning / physiology
Biological Markers / metabolism
Chronic Disease
Cytokines / biosynthesis*
Inflammation Mediators / metabolism*,  physiology
Male
Neuroglia / immunology*,  metabolism,  pathology*
Rats
Rats, Wistar
Reaction Time / immunology*
Spinal Cord / immunology*,  metabolism*
Stress, Psychological / immunology*,  psychology
Grant Support
ID/Acronym/Agency:
R01 DA026597/DA/NIDA NIH HHS; R01 DA026597-01A2/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cytokines; 0/Inflammation Mediators
Comments/Corrections

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