Document Detail


Chronic PFOS exposures induce life stage-specific behavioral deficits in adult zebrafish and produce malformation and behavioral deficits in F1 offspring.
MedLine Citation:
PMID:  23059794     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Perfluorooctane sulfonic acid (PFOS) is an organic contaminant that is ubiquitous in the environment. Few studies have assessed the behavioral effects of chronic PFOS exposure in aquatic organisms. The present study defined the behavioral effects of varying life span chronic exposures to PFOS in zebrafish. Specifically, zebrafish were exposed to control or 0.5 µM PFOS during 1 to 20, 21 to 120, or 1 to 120 d postfertilization (dpf). Exposure to PFOS impaired the adult zebrafish behavior mode under the tapping stimulus. The movement speed of male and female fish exposed for 1 to 120 dpf was significantly increased compared with control before and after tapping, whereas in the groups exposed for 1 to 20 and 21 to 120 dpf, only the males exhibited elevated swim speed before tapping. Residues of PFOS in F1 embryos derived from parental exposure for 1 to 120 and 21 to 120 dpf were significantly higher than control, and F1 embryos in these two groups also showed high malformation and mortality. The F1 larvae of parental fish exposed to PFOS for 1 to 20 or 21 to 120 dpf exhibited a higher swimming speed than control larvae in a light-to-dark behavior assessment test. The F1 larvae derived from parental fish exposed to PFOS for 1 to 120 dpf showed a significantly lower speed in the light period and a higher speed in the dark period compared with controls. Although there was little PFOS residue in embryos derived from the 1- to 20-dpf parental PFOS-exposed group, the adverse behavioral effects on both adult and F1 larvae indicate that exposure during the first 21 dpf induces long-term neurobehaviorial toxicity. The authors' findings demonstrate that chronic PFOS exposure during different life stages adversely affects adult behavior and F1 offspring morphology, behavior, and survival.
Authors:
Jiangfei Chen; Siba R Das; Jane La Du; Margaret M Corvi; Chenglian Bai; Yuanhong Chen; Xiaojuan Liu; Guonian Zhu; Robert L Tanguay; Qiaoxiang Dong; Changjiang Huang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-21
Journal Detail:
Title:  Environmental toxicology and chemistry / SETAC     Volume:  32     ISSN:  1552-8618     ISO Abbreviation:  Environ. Toxicol. Chem.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-20     Completed Date:  2013-07-23     Revised Date:  2014-06-10    
Medline Journal Info:
Nlm Unique ID:  8308958     Medline TA:  Environ Toxicol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  201-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 SETAC.
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MeSH Terms
Descriptor/Qualifier:
Alkanesulfonic Acids / toxicity*
Animals
Behavior, Animal / drug effects*
Female
Fluorocarbons / toxicity*
Larva / drug effects
Male
Toxicity Tests, Chronic
Water Pollutants, Chemical / toxicity*
Zebrafish
Grant Support
ID/Acronym/Agency:
P30 ES000210/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Alkanesulfonic Acids; 0/Fluorocarbons; 0/Water Pollutants, Chemical; 1763-23-1/perfluorooctane sulfonic acid
Comments/Corrections

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