| Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. | |
| | |
MedLine Citation:
|
PMID: 21788524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To test the hypothesis-given the increasing emphasis on quantitative computed tomographic (CT) phenotypes of chronic obstructive pulmonary disease (COPD)-that a relationship exists between COPD exacerbation frequency and quantitative CT measures of emphysema and airway disease. MATERIALS AND METHODS: This research protocol was approved by the institutional review board of each participating institution, and all participants provided written informed consent. One thousand two subjects who were enrolled in the COPDGene Study and met the GOLD (Global Initiative for Chronic Obstructive Lung Disease) criteria for COPD with quantitative CT analysis were included. Total lung emphysema percentage was measured by using the attenuation mask technique with a -950-HU threshold. An automated program measured the mean wall thickness and mean wall area percentage in six segmental bronchi. The frequency of COPD exacerbation in the prior year was determined by using a questionnaire. Statistical analysis was performed to examine the relationship of exacerbation frequency with lung function and quantitative CT measurements. RESULTS: In a multivariate analysis adjusted for lung function, bronchial wall thickness and total lung emphysema percentage were associated with COPD exacerbation frequency. Each 1-mm increase in bronchial wall thickness was associated with a 1.84-fold increase in annual exacerbation rate (P = .004). For patients with 35% or greater total emphysema, each 5% increase in emphysema was associated with a 1.18-fold increase in this rate (P = .047). CONCLUSION: Greater lung emphysema and airway wall thickness were associated with COPD exacerbations, independent of the severity of airflow obstruction. Quantitative CT can help identify subgroups of patients with COPD who experience exacerbations for targeted research and therapy development for individual phenotypes. |
| | |
Authors:
|
Meilan K Han; Ella A Kazerooni; David A Lynch; Lyrica X Liu; Susan Murray; Jeffrey L Curtis; Gerard J Criner; Victor Kim; Russell P Bowler; Nicola A Hanania; Antonio R Anzueto; Barry J Make; John E Hokanson; James D Crapo; Edwin K Silverman; Fernando J Martinez; George R Washko; |
Related Documents
:
|
8976744 - Intraorbital tissue expansion in the management of congenital anophthalmos. 10348204 - Orbital and cerebral cavernomas: comparison of clinical, neuroimaging, and neuropatholo... 9296194 - Ct-generated porous hydroxyapatite orbital floor prosthesis as a prototype bioimplant. 20152374 - Proboscis lateralis with ipsilateral sinonasal and olfactory pathway aplasia. 19921204 - Volumetric measurement of pulmonary nodules at low-dose chest ct: effect of reconstruct... 3423834 - The magnetic resonance imaging appearance at 1.5 tesla of cartilaginous tumors involvin... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-07-25 |
Journal Detail:
|
Title: Radiology Volume: 261 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-09-20 Completed Date: 2011-11-09 Revised Date: 2012-03-29 |
Medline Journal Info:
|
Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
|
Languages: eng Pagination: 274-82 Citation Subset: AIM; IM |
Copyright Information:
|
© RSNA, 2011. |
Affiliation:
|
Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA. mrking@umich.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Female Humans Male Middle Aged Phenotype Pulmonary Disease, Chronic Obstructive / genetics*, physiopathology, radiography* Severity of Illness Index Tomography, X-Ray Computed* |
| Investigator | |
Investigator/Affiliation:
|
Jeffrey Curtis / ; Ella Kazerooni / ; Nicola Hanania / ; Venkata Bandi / ; Kalpalatha Guntupalli / ; Elizabeth Guy / ; Antara Mallampalli / ; Charles Trinh / ; Mustafa Atik / ; Dawn DeMeo / ; Craig Hersh / ; George Washko / ; Francine Jacobson / ; R Graham Barr / ; Byron Thomashow / ; John Austin / ; Neil MacIntyre / ; H Page McAdams / ; Richard Rosiello / ; Timothy Bresnahan / ; Fallon Clinic / ; Charlene McEvoy / ; Joseph Tashjian / ; Robert Wise / ; Nadia Hansel / ; Robert Brown / ; Gregory Diette / ; Richard Casaburi / ; Janos Porszasz / ; Hans Fischer / ; Matt Budoff / ; Amir Sharafkhaneh / ; Charles Trinh / ; Roham Darvishi / ; Dennis Niewoehner / ; Kathryn Rice / ; Marilyn Foreman / ; Gloria Westney / ; Eugene Berkowitz / ; Russell Bowler / ; Adam Friedlander / ; David Lynch / ; John Newell / ; Gerard Criner / ; Nathaniel Marchetti / ; Aditi Satti / ; A James Mamary / ; Robert Steiner / ; Chandra Dass / ; William Bailey / ; Hrudaya Nath / ; Joe Ramsdell / ; Paul Friedman / ; San Diego / ; Geoffrey McLennan / ; Dwight Look / ; Fernando Martinez / ; Ella Kazerooni / ; Christine Wendt / ; Tadashi Allen / ; Frank Sciurba / ; Joel Weissfeld / ; Carl Fuhrman / ; Jessica Bon / ; Antonio Anzueto / ; Carlos Orozco / ; Mario Ruiz / ; San Antonio / ; James Crapo / ; Elizabeth Regan / ; Sarah Moyle / ; Douglas Stinson / ; Terri Beaty / ; Barbara Klanderman / ; Nan Laird / ; Christoph Lange / ; Michael Cho / ; Stephanie Santorico / ; John Hokanson / ; Dawn DeMeo / ; Nadia Hansel / ; Craig Hersh / ; Jacqueline Hetmanski / ; Tanda Murray / ; David Lynch / ; Joyce Schroeder / ; John Newell / ; John Reilly / ; Harvey Coxson / ; Philip Judy / ; Eric Hoffman / ; George Washko / ; Raul San Jose Estepar / ; James Ross / ; Rebecca Leek / ; Jordan Zach / ; Alex Kluiber / ; Jered Sieren / ; Heather Baumhauer / ; Verity McArthur / ; Dzimitry Kazlouski / ; Andrew Allen / ; Tanya Mann / ; Anastasia Rodionov / ; Robert Jensen / ; Homayoon Farzadegan / ; Stacey Meyerer / ; Shivam Chandan / ; Samantha Bragan / ; James Murphy / ; Douglas Everett / ; Carla Wilson / ; Ruthie Knowles / ; Amber Powell / ; Joe Piccoli / ; Maura Robinson / ; Margaret Forbes / ; Martina Wamboldt / ; John Hokanson / ; Marci Sontag / ; Jennifer Black-Shinn / ; Gregory Kinney / |
| Comments/Corrections | |
Comment In:
|
Radiology. 2012 Mar;262(3):1042; author reply 1043
[PMID:
22357905
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ultra-deep sequencing of foraminiferal microbarcodes unveils hidden richness of early monothalamous ...
Next Document: Reproducibility of CT Perfusion Parameters in Liver Tumors and Normal Liver.