Document Detail

Chronic lowering of blood pressure by carotid baroreflex activation: mechanisms and potential for hypertension therapy.
MedLine Citation:
PMID:  21357283     Owner:  NLM     Status:  MEDLINE    
Recent technical advances have renewed interest in device-based therapy for the treatment of drug-resistant hypertension. Findings from recent clinical trials regarding the efficacy of electric stimulation of the carotid sinus for the treatment of resistant hypertension are reviewed here. The main goal of this article, however, is to summarize the preclinical studies that have provided insight into the mechanisms that account for the chronic blood pressure-lowering effects of carotid baroreflex activation. Some of the mechanisms identified were predictable and confirmed by experimentation. Others have been surprising and controversial, and resolution will require further investigation. Although feasibility studies have been promising, firm conclusions regarding the value of this device-based therapy for the treatment of resistant hypertension awaits the results of current multicenter trials.
Thomas E Lohmeier; Radu Iliescu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-02-28
Journal Detail:
Title:  Hypertension     Volume:  57     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-21     Completed Date:  2011-06-30     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  880-6     Citation Subset:  IM    
Department of Physiology, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216-4505, USA.
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MeSH Terms
Baroreflex / physiology*
Blood Pressure / physiology*
Carotid Sinus / physiopathology*
Hypertension / physiopathology*
Kidney / physiopathology
Pressoreceptors / physiology
Grant Support

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