Document Detail


Chronic low-level arsenite exposure through drinking water increases blood pressure and promotes concentric left ventricular hypertrophy in female mice.
MedLine Citation:
PMID:  22215511     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiovascular disease is the leading cause of death in the United States and worldwide. High incidence of cardiovascular diseases has been linked to populations with elevated arsenic content in their drinking water. Although this correlation has been established in many epidemiological studies, a lack of experimental models to study mechanisms of arsenic-related cardiovascular pathogenesis has limited our understanding of how arsenic exposure predisposes for development of hypertension and increased cardiovascular mortality. Our studies show that mice chronically exposed to drinking water containing 100 parts per billion (ppb) sodium arsenite for 22 weeks show an increase in both systolic and diastolic blood pressure. Echocardiographic analyses as well as histological assessment show concentric left ventricular hypertrophy, a primary cardiac manifestation of chronic hypertension. Live imaging by echocardiography shows a 43% increase in left ventricular mass in arsenic-treated animals. Relative wall thickness (RWT) was calculated showing that all the arsenic-exposed animals show an RWT greater than 0.45, indicating concentric hypertrophy. Importantly, left ventricular hypertrophy, although often associated with chronic hypertension, is an independent risk factor for cardiovascular-related mortalities. These results suggest that chronic low-level arsenite exposure promotes the development of hypertension and the comorbidity of concentric hypertrophy.
Authors:
Pablo Sanchez-Soria; Derrick Broka; Sarah L Monks; Todd D Camenisch
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-01-03
Journal Detail:
Title:  Toxicologic pathology     Volume:  40     ISSN:  1533-1601     ISO Abbreviation:  Toxicol Pathol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-11     Completed Date:  2012-10-17     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7905907     Medline TA:  Toxicol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  504-12     Citation Subset:  IM    
Affiliation:
Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA. soria@pharmacy.arizona.edu
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Analysis of Variance
Animals
Arsenites / administration & dosage,  toxicity*
Blood Pressure / drug effects*
Drinking Water / standards
Echocardiography
Female
Histocytochemistry
Hypertension / chemically induced*
Hypertrophy, Left Ventricular / chemically induced*,  pathology
Mice
Sodium Compounds / administration & dosage,  toxicity*
Toxicity Tests, Chronic
Grant Support
ID/Acronym/Agency:
ES-04940/ES/NIEHS NIH HHS; P42 ES004940/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Arsenites; 0/Drinking Water; 0/Sodium Compounds; 48OVY2OC72/sodium arsenite
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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