| Chronic L-arginine supplementation enhances endurance exercise tolerance in heart failure patients. | |
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MedLine Citation:
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PMID: 16802253 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of the study was to determine the potential beneficial effect of six weeks oral L-arginine supplementation (LAS) on endurance exercise, an important determinant of daily-life activity in patients with chronic stable heart failure (CHF). After an initial incremental maximal exercise test, CHF patients performed an identical thirty-minute interval endurance exercise test before and after six weeks with (L-arginine group; ARG) or without LAS (control group; CTL). Hemodynamic, respiratory, and metabolic parameters were determined at rest, during exercise, and during recovery. Mean heart rate decreased throughout exercise and recovery after LAS (- 8.2 +/- 1.4 b x min(-1); p = 0.003 and - 6.7 +/- 1.6 b x min(-1); p < 0.001, respectively), systemic blood pressure and respiratory parameters remaining unchanged. Resting L-argininaemia increased from 102 +/- 11 to 181 +/- 37 micromol x l(-1) (p < 0.004) and exercise-induced peak increase in plasma lactate was blunted after LAS (4.13 +/- 0.75 vs. 3.13 +/- 0.39 mmol x l(-1); p = 0.02). No significant change was observed in the control group. In heart failure patients, six weeks oral LAS enhances endurance exercise tolerance, reducing both heart rate and circulating lactates. This suggests that chronic LAS might be useful as a therapeutic adjuvant in order to improve the patient's physical fitness. |
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Authors:
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S Doutreleau; B Mettauer; F Piquard; O Rouyer; A Schaefer; J Lonsdorfer; B Geny |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of sports medicine Volume: 27 ISSN: 0172-4622 ISO Abbreviation: Int J Sports Med Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-27 Completed Date: 2006-11-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008349 Medline TA: Int J Sports Med Country: Germany |
Other Details:
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Languages: eng Pagination: 567-72 Citation Subset: IM |
Affiliation:
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Service de Physiologie et d'Explorations Fonctionnelles et UPRES EA 3072, Institut de Physiologie, Faculté de Médecine, Strasbourg, France. Stephane.Doutreleau@physio-ulp.u-strasbg.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Analysis of Variance Arginine / administration & dosage, therapeutic use* Exercise Test Exercise Tolerance / drug effects*, physiology* Heart Failure / drug therapy*, physiopathology* Heart Rate / drug effects, physiology Humans Lactates / blood Middle Aged Oxygen Consumption / drug effects, physiology Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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