| Chronic kidney disease progression and outcome according to serum phosphorus in mild-to-moderate kidney dysfunction. | |
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MedLine Citation:
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PMID: 21393493 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Several factors might alter serum phosphate homeostasis and induce hyperhosphatemia in patients with chronic kidney disease (CKD) not requiring dialysis. However, whether and to what extent hyperphosphatemia is associated with a poor prognosis in different CKD patient groups remain to be elucidated. DESIGN, SETTING, PARTICIPANTS & MEASUREMENTS: We utilized the "Prevenzione Insufficienza Renale Progressiva" (PIRP) database, a large project sponsored by the Emilia-Romagna Health Institute. PIRP is a collaborative network of nephrologists and general practitioners located in the Emilia-Romagna region, Italy, aimed at increasing awareness of CKD complications and optimizing CKD patient care. We identified 1716 patients who underwent a GFR and serum phosphorous assessment between 2004 and 2007. We tested whether phosphate levels ≥4.3 mg/dl are associated with the risk of CKD progression or all causes of death. RESULTS: Older age and male sex were associated with lower phosphate levels. Instead, higher phosphate levels were noted in patients with diabetes. Patients with phosphate levels ≥4.3 mg/dl were at an increased risk of starting dialysis or dying (hazard ratio 2.04; 95% confidence interval [1.44, 2.90]). Notably, subgroup analyses revealed that the magnitude of the risk associated with hyperphosphatemia varied depending on age, sex, diabetes, and different stages of CKD. CONCLUSIONS: These analyses lend support to the hypothesis that phosphorous abnormalities might have a negative effect on the residual renal function and prognosis in different groups of CKD patients. However, the risk associated with hyperphosphatemia might vary in specific CKD patient subgroups. |
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Authors:
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Antonio Bellasi; Marcora Mandreoli; Leopoldo Baldrati; Matteo Corradini; Pierpaolo Di Nicolò; Giulio Malmusi; Antonio Santoro |
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Publication Detail:
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Type: Journal Article Date: 2011-03-10 |
Journal Detail:
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Title: Clinical journal of the American Society of Nephrology : CJASN Volume: 6 ISSN: 1555-905X ISO Abbreviation: Clin J Am Soc Nephrol Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-08 Completed Date: 2011-08-18 Revised Date: 2012-09-24 |
Medline Journal Info:
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Nlm Unique ID: 101271570 Medline TA: Clin J Am Soc Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 883-91 Citation Subset: IM |
Copyright Information:
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© 2011 by the American Society of Nephrology |
Affiliation:
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Nephrology Dialysis Hypertension Unit, Policlinico S. Orsola-Malpighi, Via P. Palagi 9, 40138 Bologna, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Chronic Disease Disease Progression Female Glomerular Filtration Rate* Humans Kidney Diseases / blood, mortality*, physiopathology Male Middle Aged Phosphorus / blood* |
| Chemical | |
Reg. No./Substance:
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7723-14-0/Phosphorus |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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