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Chronic Intermittent Low-Level Transcutaneous Electrical Stimulation of Auricular Branch of Vagus Nerve Improves Left Ventricular Remodeling in Conscious Dogs With Healed Myocardial Infarction.
MedLine Citation:
PMID:  25332149     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: -Vagus nerve stimulation (VNS) attenuates left ventricular (LV) remodeling after myocardial infarction (MI). Our previous study found a noninvasive approach to deliver VNS by transcutaneous electrical stimulation of auricular branch of vagus nerve. So we hypothesize chronic intermittent low-level tragus stimulation (LL-TS) could attenuate LV remodeling in conscious dogs with healed MI.
METHODS AND RESULTS: -Thirty beagle dogs were randomly divided into three groups, MI group (left anterior descending artery and major diagonal branches ligation to introduce MI, n=10), LL-TS group (MI plus chronic intermittent LL-TS, n=10) and Control group (sham surgery without stimulation, n=10). Tragus stimulation was delivered to bilateral tragus with ear-clips connected to a custom-made stimulator. The voltage slowing sinus rate was used as the threshold for setting LL-TS at 80% below that. LL-TS group was given four hours' stimulation at 7-9AM and 4-6PM on conscious dogs. At the end of 90-day follow-up, LL-TS group significantly reduced LA and LV dilatation, improved LV contractile and diastolic function, reduced infarct size by about 50% compared with MI group. LL-TS treatment alleviated cardiac fibrosis and significantly decreased protein expression level of collagen I, collagen III, TGF-β1, MMP-9 in LV tissues. The plasma level of hs-CRP, NE, NT-proBNP in LL-TS group was significantly lower than MI group from the 7(th) day to the end of follow-up.
CONCLUSIONS: -Chronic intermittent low-level transcutaneous electrical stimulation of auricular branch of vagus nerve can attenuate LV remodeling in conscious dogs with healed MI.
Authors:
Wang Zhuo; Yu Lilei; Wang Songyun; Huang Bing; Liao Kai; Saren Gaowa; Tan Tuantuan; Jiang Hong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-20
Journal Detail:
Title:  Circulation. Heart failure     Volume:  -     ISSN:  1941-3297     ISO Abbreviation:  Circ Heart Fail     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-21     Completed Date:  -     Revised Date:  2014-10-22    
Medline Journal Info:
Nlm Unique ID:  101479941     Medline TA:  Circ Heart Fail     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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