Document Detail


Chronic forced exercise during adolescence decreases cocaine conditioned place preference in Lewis rats.
MedLine Citation:
PMID:  20615434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic physical activity (exercise) may be beneficial in the prevention of substance use disorders; however, the extent to which physical activity can interfere with the reinforcing effects of drugs during the adolescent period, which is one of great vulnerability for drug experimentation, has not been fully evaluated. Here, we assess the effects of chronic forced exercise during adolescence on preference for cocaine using the conditioned place preference (CPP) paradigm in male and female Lewis rats. The group of rats exposed to exercise ran on a treadmill for 6 weeks on a progressive time-increased schedule for up to 1h of exercise per day, while the groups of sedentary rats remained in their home cage. Following the 6 weeks of exercise exposure, rats were tested for cocaine CPP. Results showed that chronic exercise significantly attenuated cocaine CPP in both males and females compared to a sedentary environment. Furthermore, male exercise rats failed to show significant cocaine CPP. In contrast, female exercise rats still showed cocaine CPP but it was significantly reduced compared to the female sedentary rats. Females also exhibited greater cocaine CPP than males overall. These findings suggest that strategies to promote physical activity during adolescence may be protective against cocaine abuse in both males and females, and these findings merit further investigation. We also corroborate a gender-specific sensitivity to the reinforcing effects of cocaine, highlighting the need to consider gender-tailored exercise interventions for drug abuse prevention.
Authors:
Panayotis K Thanos; Andrew Tucci; Joshua Stamos; Lisa Robison; Gene-Jack Wang; Brenda J Anderson; Nora D Volkow
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-07-06
Journal Detail:
Title:  Behavioural brain research     Volume:  215     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-08-23     Completed Date:  2010-12-06     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  IM    
Copyright Information:
Copyright 2010. Published by Elsevier B.V.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Cocaine / pharmacology*
Conditioning (Psychology) / drug effects,  physiology*
Dopamine Uptake Inhibitors / pharmacology
Female
Male
Physical Conditioning, Animal / physiology*
Rats
Rats, Inbred Lew
Reward
Grant Support
ID/Acronym/Agency:
AA 11034/AA/NIAAA NIH HHS; AA07574/AA/NIAAA NIH HHS; AA07611/AA/NIAAA NIH HHS; ZIA AA000551-08/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Dopamine Uptake Inhibitors; I5Y540LHVR/Cocaine
Comments/Corrections

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