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Chronic Effects of Pulmonary Artery Stenosis on Hemodynamic and Structural Development of the Lungs.
MedLine Citation:
PMID:  23043077     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Pulmonary artery (PA) stenosis is a difficult obstructive defect to manage as clinicians cannot know a priori which obstructions to treat and when. Prognosis of PA stenosis and its chronic effects on lung development are poorly understood. This study aimed to characterize the hemodynamic and structural effects of PA stenosis during development. Fourteen male Sprague-Dawley rats underwent left pulmonary artery (LPA) banding at age 21 days and thirteen underwent sham-operation. Hemodynamic and structural impacts were studied longitudinally at 20, 36, 52, 100 and 160 days. Chronic LPA banding resulted in a significant reduction in LPA flow (p<0.0001) and size of both proximal LPA (p<0.0001) and distal LPA (p<0.01), as well as a significant increase in flow and size of the right pulmonary artery (p<0.05) throughout development. Flows and sizes adapted such that normal levels of wall shear were restored after banding. At 160 days, LPA banding resulted in a significant decrease in left lung volume and an increase in right lung volume but no significant differences in total lung volume. There was an elevation of proximal LPA pressure as well as right ventricular hypertrophy in the banded animals. The banded lung exhibited arterial disorganization, loss of vessels and enlargement of its bronchial arteries, while the contralateral lung showed signs of vascular pathology. There are consequences on development of both lungs in the presence of an LPA stenosis at young age. These results suggest that early intervention may be necessary to optimize left lung growth and minimize right lung vascular pathology.
Authors:
Hedi Razavi; Sarah E Stewart; Chengpei Xu; Hirofumi Sawada; Shahrzad Yeganeh Zarafshar; Charles A Taylor; Marlene Rabinovitch; Jeffrey Allan Feinstein
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-5
Journal Detail:
Title:  American journal of physiology. Lung cellular and molecular physiology     Volume:  -     ISSN:  1522-1504     ISO Abbreviation:  Am. J. Physiol. Lung Cell Mol. Physiol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901229     Medline TA:  Am J Physiol Lung Cell Mol Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Stanford University.
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