Document Detail


Chronic Chlamydia pneumoniae infection increases the risk of occlusion of lumbar segmental arteries of patients with sciatica: a 3-year follow-up study.
MedLine Citation:
PMID:  12897506     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
STUDY DESIGN: A magnetic resonance imaging follow-up study of lumbar arteries among patients with sciatica with chronic Chlamydia pneumoniae infection. OBJECTIVE: To determine whether chronic infection causes occlusion of lumbar arteries. SUMMARY OF BACKGROUND DATA: C. pneumoniae infection is associated with coronary heart disease, and the infectious pathogen has also been detected in abdominal aortic aneurysms and in atherosclerotic plaques. No studies are available on the effect of this infectious agent on lumbar arteries. METHODS: Chronic infection was defined as persistent high positive immunoglobulin G and/or immunoglobulin A antibodies and/or the presence of immune complexes. The lumbar arteries, evaluated with two-dimensional time-of-flight magnetic resonance angiography, were scored as normal, narrowed, or occluded. The differences in the segmental and whole lumbar spine (segments L1-L4) sum of arterial occlusion at baseline and at 3 years, and the incidence of new arterial stenosis were compared in patients with and without chronic infection using the Kolmogorov-Smirnov test. RESULTS: Patients with chronic infection were more likely to be persistent smokers (P = 0.006), male (P = 0.04), and more obese (P = 0.02) compared to patients with normal antibody levels. They had significantly higher degree of arterial stenosis at L4 segment at baseline and at 3 years (P = 0.001 and 0.002, respectively), in the whole lumbar spine at baseline and at 3 years (P < 0.001 for both), and at L1 and L3 segments at 3 years (P = 0.013 for both). The incidence of new arterial stenosis was similar in both patient groups. Patients with chronic infection also had significantly higher grade of endplate degeneration at L4-L5 (P = 0.008). CONCLUSIONS: The results of this study suggest that chronic C. pneumoniae infection may induce stenosis of lumbar arteries.
Authors:
Jaro Karppinen; Paula Mikkonen; Mauno Kurunlahti; Osmo Tervonen; Mika Paldanius; Pekka Vasari; Pekka Saikku; Heikki Vanharanta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Spine     Volume:  28     ISSN:  1528-1159     ISO Abbreviation:  Spine     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-04     Completed Date:  2004-02-20     Revised Date:  2009-07-09    
Medline Journal Info:
Nlm Unique ID:  7610646     Medline TA:  Spine (Phila Pa 1976)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E284-9     Citation Subset:  IM    
Affiliation:
Department of Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland. jaro.karppinen@ttl.fi
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Bacterial / blood
Antigen-Antibody Complex / blood
Arterial Occlusive Diseases / diagnosis*,  epidemiology*
Case-Control Studies
Chlamydophila Infections / epidemiology*,  physiopathology
Chronic Disease
Comorbidity
Female
Finland / epidemiology
Follow-Up Studies
Humans
Incidence
Lumbosacral Region / blood supply,  physiopathology
Magnetic Resonance Angiography
Magnetic Resonance Imaging
Male
Middle Aged
Obesity / epidemiology
Risk
Risk Assessment
Sciatica / epidemiology*,  microbiology,  physiopathology
Sex Factors
Smoking / epidemiology
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Antigen-Antibody Complex

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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