| Chronic Chlamydia pneumoniae infection increases the risk of occlusion of lumbar segmental arteries of patients with sciatica: a 3-year follow-up study. | |
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MedLine Citation:
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PMID: 12897506 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY DESIGN: A magnetic resonance imaging follow-up study of lumbar arteries among patients with sciatica with chronic Chlamydia pneumoniae infection. OBJECTIVE: To determine whether chronic infection causes occlusion of lumbar arteries. SUMMARY OF BACKGROUND DATA: C. pneumoniae infection is associated with coronary heart disease, and the infectious pathogen has also been detected in abdominal aortic aneurysms and in atherosclerotic plaques. No studies are available on the effect of this infectious agent on lumbar arteries. METHODS: Chronic infection was defined as persistent high positive immunoglobulin G and/or immunoglobulin A antibodies and/or the presence of immune complexes. The lumbar arteries, evaluated with two-dimensional time-of-flight magnetic resonance angiography, were scored as normal, narrowed, or occluded. The differences in the segmental and whole lumbar spine (segments L1-L4) sum of arterial occlusion at baseline and at 3 years, and the incidence of new arterial stenosis were compared in patients with and without chronic infection using the Kolmogorov-Smirnov test. RESULTS: Patients with chronic infection were more likely to be persistent smokers (P = 0.006), male (P = 0.04), and more obese (P = 0.02) compared to patients with normal antibody levels. They had significantly higher degree of arterial stenosis at L4 segment at baseline and at 3 years (P = 0.001 and 0.002, respectively), in the whole lumbar spine at baseline and at 3 years (P < 0.001 for both), and at L1 and L3 segments at 3 years (P = 0.013 for both). The incidence of new arterial stenosis was similar in both patient groups. Patients with chronic infection also had significantly higher grade of endplate degeneration at L4-L5 (P = 0.008). CONCLUSIONS: The results of this study suggest that chronic C. pneumoniae infection may induce stenosis of lumbar arteries. |
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Authors:
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Jaro Karppinen; Paula Mikkonen; Mauno Kurunlahti; Osmo Tervonen; Mika Paldanius; Pekka Vasari; Pekka Saikku; Heikki Vanharanta |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Spine Volume: 28 ISSN: 1528-1159 ISO Abbreviation: Spine Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-08-04 Completed Date: 2004-02-20 Revised Date: 2009-07-09 |
Medline Journal Info:
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Nlm Unique ID: 7610646 Medline TA: Spine (Phila Pa 1976) Country: United States |
Other Details:
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Languages: eng Pagination: E284-9 Citation Subset: IM |
Affiliation:
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Department of Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland. jaro.karppinen@ttl.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Bacterial / blood Antigen-Antibody Complex / blood Arterial Occlusive Diseases / diagnosis*, epidemiology* Case-Control Studies Chlamydophila Infections / epidemiology*, physiopathology Chronic Disease Comorbidity Female Finland / epidemiology Follow-Up Studies Humans Incidence Lumbosacral Region / blood supply, physiopathology Magnetic Resonance Angiography Magnetic Resonance Imaging Male Middle Aged Obesity / epidemiology Risk Risk Assessment Sciatica / epidemiology*, microbiology, physiopathology Sex Factors Smoking / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Antigen-Antibody Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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