Document Detail


Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis.
MedLine Citation:
PMID:  23217257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Caloric restriction (CR) mitigates many detrimental effects of aging and prolongs life span. CR has been suggested to increase mitochondrial biogenesis, thereby attenuating age-related declines in mitochondrial function, a concept that is challenged by recent studies. Here we show that lifelong CR in mice prevents age-related loss of mitochondrial oxidative capacity and efficiency, measured in isolated mitochondria and permeabilized muscle fibers. We find that these beneficial effects of CR occur without increasing mitochondrial abundance. Whole-genome expression profiling and large-scale proteomic surveys revealed expression patterns inconsistent with increased mitochondrial biogenesis, which is further supported by lower mitochondrial protein synthesis with CR. We find that CR decreases oxidant emission, increases antioxidant scavenging, and minimizes oxidative damage to DNA and protein. These results demonstrate that CR preserves mitochondrial function by protecting the integrity and function of existing cellular components rather than by increasing mitochondrial biogenesis.
Authors:
Ian R Lanza; Piotrek Zabielski; Katherine A Klaus; Dawn M Morse; Carrie J Heppelmann; H Robert Bergen; Surendra Dasari; Stephane Walrand; Kevin R Short; Matthew L Johnson; Matthew M Robinson; Jill M Schimke; Daniel R Jakaitis; Yan W Asmann; Zhifu Sun; K Sreekumaran Nair
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell metabolism     Volume:  16     ISSN:  1932-7420     ISO Abbreviation:  Cell Metab.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  2013-05-22     Revised Date:  2013-12-11    
Medline Journal Info:
Nlm Unique ID:  101233170     Medline TA:  Cell Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  777-88     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Data Bank Information
Bank Name/Acc. No.:
GEO/GSE36285
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MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Caloric Restriction*
DNA, Mitochondrial / metabolism
Down-Regulation
Electron Transport Complex I / metabolism
Electron Transport Complex II / metabolism
Gene Expression Profiling
Mice
Mitochondria / genetics,  metabolism*
Mitochondrial Proteins / genetics,  metabolism
Mitochondrial Turnover / physiology*
Muscle Proteins / metabolism
Muscle, Skeletal / metabolism
Oxidative Stress
Proteomics
Transcriptome
Grant Support
ID/Acronym/Agency:
KL2 TR000136/TR/NCATS NIH HHS; KL2TR000136-07/TR/NCATS NIH HHS; R01 AG009531/AG/NIA NIH HHS; R01-AG09531/AG/NIA NIH HHS; T32 DK007198/DK/NIDDK NIH HHS; T32 DK007198/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Mitochondrial; 0/Mitochondrial Proteins; 0/Muscle Proteins; EC 1.3.5.1/Electron Transport Complex II; EC 1.6.5.3/Electron Transport Complex I
Comments/Corrections

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