Document Detail


Chronic Budd-Chiari syndrome as a rare complication of Crohn's disease: a case report.
MedLine Citation:
PMID:  19543104     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Budd-Chiari syndrome (BCS) is characterized by hepatic venous outflow obstruction involving the hepatic veins, inferior vena cava, or both. BCS has occasionally been reported in the literature as a very rare complication of ulcerative colitis. However, association of Crohn's disease (CD) and BCS is extremely rare with only a single case reported in the world literature to date. We report a case of a young woman with chronically active, therapy-resistant CD who developed massive ascites, elevation of liver enzymes, and coagulopathy in the course of her disease. She was subsequently diagnosed with BCS for which a successful liver transplantation was performed. Chronically active therapy resistant CD and methylenetetrahydrofolate reductase gene mutation have been identified as possible risk factors for development of BCS in this patient.
Authors:
Marko Brinar; Irena Hrstic; Silvija Cukovic-Cavka; Ranka Stern Padovan; Silva Zupancic-Salek; Boris Vucelic
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  22     ISSN:  1473-5687     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  761-4     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology, University Hospital Zagreb - Rebro, Kispaticeva 12, Zagreb 10000, Croatia. marko.brinar@zg.htnet.hr
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use
Ascites / pathology,  radiography
Budd-Chiari Syndrome / etiology,  radiography*,  surgery*
Crohn Disease / complications*
Female
Hepatic Veins / radiography
Humans
Immunosuppressive Agents / therapeutic use
Liver / pathology,  radiography
Liver Transplantation*
Methylenetetrahydrofolate Reductase (NADPH2) / genetics
Mutation
Phlebography
Risk Factors
Tacrolimus / therapeutic use
Tomography, X-Ray Computed
Vena Cava, Inferior / radiography
Warfarin / therapeutic use
Young Adult
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Immunosuppressive Agents; 109581-93-3/Tacrolimus; 81-81-2/Warfarin; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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