| Chronic Air Pollution Exposure during Pregnancy and Maternal and Fetal C-reactive Protein Levels. The Generation R Study. | |
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MedLine Citation:
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PMID: 22306530 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Exposure to air pollution has been associated with higher C-reactive protein (CRP) levels, suggesting an inflammatory response. Not much is known about this association in pregnancy. Objectives: We investigated the associations of air pollution exposure during pregnancy with maternal and fetal CRP levels in a population-based cohort study in the Netherlands. Methods: PM10 and NO2 levels were estimated at the home address using dispersion modelling for different averaging periods preceding the blood sampling (1 week, 2 weeks, 4 weeks, and total pregnancy). High-sensitivity CRP levels were measured in maternal blood samples in early pregnancy (n = 5067) and in fetal cord blood samples at birth (n = 4450). Results: As compared to the lowest quartile, higher PM10 exposure levels for the prior one and two weeks were associated with elevated maternal CRP levels (>8 mg/L) in the first trimester (odds ratio (OR) 1.32, 95% confidence interval (CI) 1.08 to 1.61 for the fourth PM10 quartile for the prior week, and OR 1.28, 95% CI 1.06 to 1.56 for the third PM10 quartile for the prior two weeks), however, no clear dose-response relationships were observed. PM10 and NO2 exposure levels for one, two, and four weeks preceding delivery were not consistently associated with fetal CRP levels at delivery. Higher long-term PM10 and NO2 exposure levels (total pregnancy) were associated with elevated fetal CRP levels (>1 mg/L) at delivery (OR 2.18, 95% CI 1.08 to 4.38 and OR 3.42, 95% CI 1.36 to 8.58 for the fourth quartiles of PM10 and NO2, respectively; P-values for trend <0.05). Conclusions: Our results suggest that exposure to air pollution during pregnancy may lead to maternal and fetal inflammatory responses. |
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Authors:
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Edith H van den Hooven; Yvonne de Kluizenaar; Frank H Pierik; Albert Hofman; Sjoerd W van Ratingen; Peter Yj Zandveld; Jan Lindemans; Henk Russcher; Eric A P Steegers; Henk Me Miedema; Vincent Wv Jaddoe |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-03 |
Journal Detail:
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Title: Environmental health perspectives Volume: - ISSN: 1552-9924 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0330411 Medline TA: Environ Health Perspect Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Erasmus Medical Center. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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