| Chronic ACE inhibition reduces intimal hyperplasia in experimental vein grafts. | |
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MedLine Citation:
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PMID: 1741654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intimal hyperplasia is an important factor in the pathophysiology of vein graft failure. Local renin-angiotensin systems recently have been shown to modulate the development of intimal hyperplasia in arteries after intimal injury. The effect of chronic angiotensin-converting enzyme (ACE) inhibition on the development of intimal hyperplasia in experimental vein grafts was examined in this study. Ten New Zealand White rabbits received 10 mg/kg of captopril daily in their drinking water. One week later the right carotid artery was divided and bypassed with the reversed right external jugular vein in these rabbits and in 10 matched controls. Captopril was continued for 28 days after operation, when all the grafts were harvested. Five grafts from each group were perfusion fixed, and the intimal thickness in the proximal, middle, and distal segments was determined. Rings from the remaining grafts (n = 20 in each group) were studied in vitro under isometric tension, and their responses to norepinephrine (NE), histamine (HIST), serotonin (5-HT), angiotensin I (AI), and angiotensin II (AII) was measured. The intimal thickness of the proximal, middle, and distal segments of the captopril-treated grafts were significantly less than controls, being reduced in all segments by approximately 40% (p less than 0.0001). With regard to vasoreactivity, the captopril-treated grafts were hypersensitive to 5-HT (control ED50 5.5 +/- 0.5 X 10(-7) mol/L vs. captopril-treated 1.1 +/- 0.2 X 10(-6) mol/L; p less than 0.005) although the maximal response was significantly reduced (control 1.6 +/- 0.3 g vs. captopril-treated 0.8 +/- 0.1 g; p less than 0.05). There were no differences in sensitivity between control and captopril-treated rings with respect to NE, HIST, AI, or AII. Four of the ten captopril-treated segments, however, failed to respond to AI, and the maximal active tension of the responders was significantly reduced (control 0.47 +/- 0.06 g vs. 0.20 +/- 0.05 g; p less than 0.02). These results suggest that ACE is involved in the modulation of vein graft intimal hyperplasia, and that ACE inhibitors may have therapeutic applications in patients undergoing vein bypass procedures. |
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Authors:
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M K O'Donohoe; L B Schwartz; Z S Radic; E M Mikat; R L McCann; P O Hagen |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of surgery Volume: 214 ISSN: 0003-4932 ISO Abbreviation: Ann. Surg. Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1992-01-06 Completed Date: 1992-01-06 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372354 Medline TA: Ann Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 727-32 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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pharmacology* Animals Blood Pressure / drug effects Captopril / pharmacology* Histamine / analysis Hyperplasia / pathology Male Muscle, Smooth, Vascular / drug effects, pathology Norepinephrine / analysis Rabbits Renin-Angiotensin System / physiology Serotonin / analysis Vasomotor System / physiology Veins / drug effects, pathology, transplantation* |
| Grant Support | |
ID/Acronym/Agency:
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HL 15448/HL/NHLBI NIH HHS; HL08086/HL/NHLBI NIH HHS; HL32720/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 51-45-6/Histamine; 62571-86-2/Captopril |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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