Document Detail


Chromosomes of human sperm: variability among normal individuals.
MedLine Citation:
PMID:  3838965     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The chromosomal constitution of 2468 human sperm cells has been investigated by fusion of human sperm with hamster eggs. The overall frequency of cells with structural aberrations was 7.7%, ranging from 1.9% to 15.8%, and varying significantly among individuals. The highest frequency occurred in sperm from the oldest donor (49 years), who also had had a vasectomy reversal three years prior to sampling. The overall aneuploidy frequency was 1.7%, ranging from 0.6% to 3.1%. In nine out of ten donors from whom blood samples were available the frequency of sperm cells with structural aberrations was higher than that for lymphocytes. Two previously reported donors (Brandriff et al. 1984) were resampled after an interval of 14 and 16 months respectively, and were each found to have similar frequencies of sperm chromosome abnormalities at both sampling times. A father-son pair included in the study had several chromosome breakpoints in common, although no more frequently than unrelated individuals.
Authors:
B Brandriff; L Gordon; L Ashworth; G Watchmaker; D Moore; A J Wyrobek; A V Carrano
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Human genetics     Volume:  70     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1985  
Date Detail:
Created Date:  1985-07-15     Completed Date:  1985-07-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  18-24     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aneuploidy
Animals
Chromosome Aberrations*
Cricetinae
Female
Genetic Variation
Humans
Karyotyping
Lymphocytes / ultrastructure
Male
Middle Aged
Sperm-Ovum Interactions
Spermatozoa / ultrastructure*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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