Document Detail


Chromosome-wide linkage disequilibrium caused by an inversion polymorphism in the white-throated sparrow (Zonotrichia albicollis).
MedLine Citation:
PMID:  20571514     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chromosomal inversions have been of long-standing interest to geneticists because they are capable of suppressing recombination and facilitating the formation of adaptive gene complexes. An exceptional inversion polymorphism (ZAL2(m)) in the white-throated sparrow (Zonotrichia albicollis) is linked to variation in plumage, social behavior and mate choice, and is maintained in the population by negative assortative mating. The ZAL2(m) polymorphism is a complex inversion spanning > 100 Mb and has been proposed to be a strong suppressor of recombination, as well as a potential model for studying neo-sex chromosome evolution. To quantify and evaluate these features of the ZAL2(m) polymorphism, we generated sequence from 8 ZAL2(m) and 16 ZAL2 chromosomes at 58 loci inside and 4 loci outside the inversion. Inside the inversion we found that recombination was completely suppressed between ZAL2 and ZAL2(m), resulting in uniformly high levels of genetic differentiation (F(ST)=0.94), the formation of two distinct haplotype groups representing the alternate chromosome arrangements and extensive linkage disequilibrium spanning ~104 Mb within the inversion, whereas gene flow was not suppressed outside the inversion. Finally, although ZAL2(m) homozygotes are exceedingly rare in the population, occurring at a frequency of < 1%, we detected evidence of historical recombination between ZAL2(m) chromosomes inside the inversion, refuting its potential status as a non-recombining autosome.
Authors:
L Y Huynh; D L Maney; J W Thomas
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-06-23
Journal Detail:
Title:  Heredity     Volume:  106     ISSN:  1365-2540     ISO Abbreviation:  Heredity (Edinb)     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-23     Completed Date:  2011-07-12     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  0373007     Medline TA:  Heredity (Edinb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  537-46     Citation Subset:  IM    
Data Bank Information
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromosome Inversion*
Chromosomes / genetics*
Linkage Disequilibrium*
Molecular Sequence Data
Phylogeny
Polymorphism, Genetic*
Recombination, Genetic
Sparrows / classification,  genetics*
Grant Support
ID/Acronym/Agency:
1R21MH082046/MH/NIMH NIH HHS; R21 MH082046/MH/NIMH NIH HHS; R21 MH082046-02/MH/NIMH NIH HHS
Comments/Corrections

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