Document Detail

Chromosome-wide linkage disequilibrium caused by an inversion polymorphism in the white-throated sparrow (Zonotrichia albicollis).
MedLine Citation:
PMID:  20571514     Owner:  NLM     Status:  MEDLINE    
Chromosomal inversions have been of long-standing interest to geneticists because they are capable of suppressing recombination and facilitating the formation of adaptive gene complexes. An exceptional inversion polymorphism (ZAL2(m)) in the white-throated sparrow (Zonotrichia albicollis) is linked to variation in plumage, social behavior and mate choice, and is maintained in the population by negative assortative mating. The ZAL2(m) polymorphism is a complex inversion spanning > 100 Mb and has been proposed to be a strong suppressor of recombination, as well as a potential model for studying neo-sex chromosome evolution. To quantify and evaluate these features of the ZAL2(m) polymorphism, we generated sequence from 8 ZAL2(m) and 16 ZAL2 chromosomes at 58 loci inside and 4 loci outside the inversion. Inside the inversion we found that recombination was completely suppressed between ZAL2 and ZAL2(m), resulting in uniformly high levels of genetic differentiation (F(ST)=0.94), the formation of two distinct haplotype groups representing the alternate chromosome arrangements and extensive linkage disequilibrium spanning ~104 Mb within the inversion, whereas gene flow was not suppressed outside the inversion. Finally, although ZAL2(m) homozygotes are exceedingly rare in the population, occurring at a frequency of < 1%, we detected evidence of historical recombination between ZAL2(m) chromosomes inside the inversion, refuting its potential status as a non-recombining autosome.
L Y Huynh; D L Maney; J W Thomas
Related Documents :
6357944 - Selection and endpoint distribution of bacterial inversion mutations.
3612704 - Pericentric inversion in human chromosome 1 and the risk for male sterility.
6804304 - Techniques for manipulating chromosomal rearrangements and their application to drosoph...
955624 - Structural variability of human chromosome 9 in relation to its evolution.
2891614 - The same mhc recombinational hot spots are active in crossing-over between wild/wild an...
10515604 - Chromosomal localization of ests obtained from human fetal liver via bac-mediated fish ...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-06-23
Journal Detail:
Title:  Heredity     Volume:  106     ISSN:  1365-2540     ISO Abbreviation:  Heredity (Edinb)     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-23     Completed Date:  2011-07-12     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  0373007     Medline TA:  Heredity (Edinb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  537-46     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
GENBANK/GU449138;  GU449139;  GU449140;  GU449141;  GU449142;  GU449143;  GU449144;  GU449145;  GU449146;  GU449147;  GU449148;  GU449149;  GU449150;  GU449151;  GU449152;  GU449153;  GU449154;  GU449155;  GU449156;  GU449157;  GU449158;  GU449159;  GU449160;  GU449161;  GU449162;  GU449163;  GU449164;  GU449165;  GU449166;  GU449167;  GU449168;  GU449169;  GU449170;  GU449171;  GU449172;  GU449173;  GU449174;  GU449175;  GU449176;  GU449177;  GU449178;  GU449179;  GU449180;  GU449181;  GU449182;  GU449183;  GU449184;  GU449185;  GU449186;  GU449187;  GU449188;  GU449189;  GU449190;  GU449191;  GU449192;  GU449193;  GU449194;  GU449195;  GU449196;  GU449197;  GU449198;  GU449199;  GU449200;  GU449201;  GU449202;  GU449203;  GU449204;  GU449205;  GU449206;  GU449207;  GU449208;  GU449209;  GU449210;  GU449211;  GU449212;  GU449213;  GU449214;  GU449215;  GU449216;  GU449217;  GU449218;  GU449219;  GU449220;  GU449221;  GU449222;  GU449223;  GU449224;  GU449225;  GU449226;  GU449227;  GU449228;  GU449229;  GU449230;  GU449231;  GU449232;  GU449233;  GU449234;  GU449235;  GU449236;  GU449237;  GU449238;  GU449239;  GU449240;  GU449241;  GU449242;  GU449243;  GU449244;  GU449245;  GU449246;  GU449247;  GU449248;  GU449249;  GU449250;  GU449251;  GU449252;  GU449253;  GU449254;  GU449255;  GU449256;  GU449257;  GU449258;  GU449259;  GU449260;  GU449261;  GU449262;  GU449263;  GU449264;  GU449265;  GU449266;  GU449267;  GU449268;  GU449269;  GU449270;  GU449271;  GU449272;  GU449273;  GU449274;  GU449275;  GU449276;  GU449277;  GU449278;  GU449279;  GU449280;  GU449281;  GU449282;  GU449283;  GU449284;  GU449285;  GU449286;  GU449287;  GU449288;  GU449289;  GU449290;  GU449291;  GU449292;  GU449293;  GU449294;  GU449295;  GU449296;  GU449297;  GU449298;  GU449299;  GU449300;  GU449301;  GU449302;  GU449303;  GU449304;  GU449305;  GU449306;  GU449307;  GU449308;  GU449309;  GU449310;  GU449311;  GU449312;  GU449313;  GU449314;  GU449315;  GU449316;  GU449317;  GU449318;  GU449319;  GU449320;  GU449321;  GU449322;  GU449323;  GU449324;  GU449325;  GU449326;  GU449327;  GU449328;  GU449329;  GU449330;  GU449331;  GU449332;  GU449333;  GU449334;  GU449335;  GU449336;  GU449337;  GU449338;  GU449339;  GU449340;  GU449341;  GU449342;  GU449343;  GU449344;  GU449345;  GU449346;  GU449347;  GU449348;  GU449349;  GU449350;  GU449351;  GU449352;  GU449353;  GU449354;  GU449355;  GU449356;  GU449357;  GU449358;  GU449359;  GU449360;  GU449361;  GU449362;  GU449363;  GU449364;  GU449365;  GU449366;  GU449367;  GU449368;  GU449369;  GU449370;  GU449371;  GU449372;  GU449373;  GU449374;  GU449375;  GU449376;  GU449377;  GU449378;  GU449379;  GU449380;  GU449381;  GU449382;  GU449383;  GU449384;  GU449385;  GU449386;  GU449387;  GU449388;  GU449389;  GU449390;  GU449391;  GU449392;  GU449393;  GU449394;  GU449395;  GU449396;  GU449397;  GU449398;  GU449399;  GU449400;  GU449401;  GU449402;  GU449403;  GU449404;  GU449405;  GU449406;  GU449407;  GU449408;  GU449409;  GU449410;  GU449411;  GU449412;  GU449413;  GU449414;  GU449415;  GU449416;  GU449417;  GU449418;  GU449419;  GU449420;  GU449421;  GU449422;  GU449423;  GU449424;  GU449425;  GU449426;  GU449427;  GU449428;  GU449429;  GU449430;  GU449431;  GU449432;  GU449433;  GU449434;  GU449435;  GU449436;  GU449437;  GU449438;  GU449439;  GU449440;  GU449441;  GU449442;  GU449443;  GU449444;  GU449445;  GU449446;  GU449447;  GU449448;  GU449449;  GU449450;  GU449451;  GU449452;  GU449453;  GU449454;  GU449455;  GU449456;  GU449457;  GU449458;  GU449459;  GU449460;  GU449461;  GU449462;  GU449463;  GU449464;  GU449465;  GU449466;  GU449467;  GU449468;  GU449469;  GU449470;  GU449471;  GU449472;  GU449473;  GU449474;  GU449475;  GU449476;  GU449477;  GU449478;  GU449479;  GU449480;  GU449481;  GU449482;  GU449483;  GU449484;  GU449485;  GU449486;  GU449487;  GU449488;  GU449489;  GU449490;  GU449491;  GU449492;  GU449493;  GU449494;  GU449495;  GU449496;  GU449497;  GU449498;  GU449499;  GU449500;  GU449501;  GU449502;  GU449503;  GU449504;  GU449505;  GU449506;  GU449507;  GU449508;  GU449509;  GU449510;  GU449511;  GU449512;  GU449513;  GU449514;  GU449515;  GU449516;  GU449517;  GU449518;  GU449519;  GU449520;  GU449521;  GU449522;  GU449523;  GU449524;  GU449525;  GU449526;  GU449527;  GU449528;  GU449529;  GU449530;  GU449531;  GU449532;  GU449533;  GU449534;  GU449535;  GU449536;  GU449537;  GU449538;  GU449539;  GU449540;  GU449541;  GU449542;  GU449543;  GU449544;  GU449545;  GU449546;  GU449547;  GU449548;  GU449549;  GU449550;  GU449551;  GU449552;  GU449553;  GU449554;  GU449555;  GU449556;  GU449557;  GU449558;  GU449559;  GU449560;  GU449561;  GU449562;  GU449563;  GU449564;  GU449565;  GU449566;  GU449567;  GU449568;  GU449569;  GU449570;  GU449571;  GU449572;  GU449573;  GU449574;  GU449575;  GU449576;  GU449577;  GU449578;  GU449579;  GU449580;  GU449581;  GU449582;  GU449583;  GU449584;  GU449585;  GU449586;  GU449587;  GU449588;  GU449589;  GU449590;  GU449591;  GU449592;  GU449593;  GU449594;  GU449595;  GU449596;  GU449597;  GU449598;  GU449599;  GU449600;  GU449601;  GU449602;  GU449603;  GU449604;  GU449605;  GU449606;  GU449607;  GU449608;  GU449609;  GU449610;  GU449611;  GU449612;  GU449613;  GU449614;  GU449615;  GU449616;  GU449617;  GU449618;  GU449619;  GU449620;  GU449621;  GU449622;  GU449623;  GU449624;  GU449625;  GU449626;  GU449627;  GU449628;  GU449629;  GU449630;  GU449631;  GU449632;  GU449633;  GU449634;  GU449635;  GU449636;  GU449637;  GU449638;  GU449639;  GU449640;  GU449641;  GU449642;  GU449643;  GU449644;  GU449645;  GU449646;  GU449647;  GU449648;  GU449649;  GU449650;  GU449651;  GU449652;  GU449653;  GU449654;  GU449655;  GU449656;  GU449657;  GU449658;  GU449659;  GU449660;  GU449661;  GU449662;  GU449663;  GU449664;  GU449665;  GU449666;  GU449667;  GU449668;  GU449669;  GU449670;  GU449671;  GU449672;  GU449673;  GU449674;  GU449675;  GU449676;  GU449677;  GU449678;  GU449679;  GU449680;  GU449681;  GU449682;  GU449683;  GU449684;  GU449685;  GU449686;  GU449687;  GU449688;  GU449689;  GU449690;  GU449691;  GU449692;  GU449693;  GU449694;  GU449695;  GU449696;  GU449697;  GU449698;  GU449699;  GU449700;  GU449701;  GU449702;  GU449703;  GU449704;  GU449705;  GU449706;  GU449707;  GU449708;  GU449709;  GU449710;  GU449711;  GU449712;  GU449713;  GU449714;  GU449715;  GU449716;  GU449717;  GU449718;  GU449719;  GU449720;  GU449721;  GU449722;  GU449723;  GU449724;  GU449725;  GU449726;  GU449727;  GU449728;  GU449729;  GU449730;  GU449731;  GU449732;  GU449733;  GU449734;  GU449735;  GU449736;  GU449737;  GU449738;  GU449739;  GU449740;  GU449741;  GU449742;  GU449743;  GU449744;  GU449745;  GU449746;  GU449747;  GU449748;  GU449749;  GU449750;  GU449751;  GU449752;  GU449753;  GU449754;  GU449755;  GU449756;  GU449757;  GU449758;  GU449759;  GU449760;  GU449761;  GU449762;  GU449763;  GU449764;  GU449765;  GU449766;  GU449767;  GU449768;  GU449769;  GU449770;  GU449771;  GU449772;  GU449773;  GU449774;  GU449775;  GU449776;  GU449777;  GU449778;  GU449779;  GU449780;  GU449781;  GU449782;  GU449783;  GU449784;  GU449785;  GU449786;  GU449787;  GU449788;  GU449789;  GU449790;  GU449791;  GU449792;  GU449793;  GU449794;  GU449795;  GU449796;  GU449797;  GU449798;  GU449799;  GU449800;  GU449801;  GU449802;  GU449803;  GU449804;  GU449805;  GU449806;  GU449807;  GU449808;  GU449809;  GU449810;  GU449811;  GU449812;  GU449813;  GU449814;  GU449815;  GU449816;  GU449817;  GU449818;  GU450220;  GU450221;  GU450222;  GU450223;  GU450224;  GU450225;  GU450226;  GU450227;  GU450228;  GU450229;  GU450230;  GU450231;  GU450232;  GU450233;  GU450234;  GU450235;  GU450236;  GU450237;  GU450238;  GU450239;  GU450240;  GU450241;  GU450242;  GU450243;  GU450244;  GU450245;  GU450246;  GU450247;  GU450248;  GU450249;  GU450250;  GU450251;  GU450252;  GU450253;  GU450254;  GU450255;  GU450256;  GU450257;  GU450258;  GU450259;  GU450260;  GU450261;  GU450262;  GU450263;  GU450264;  GU450265;  GU450266;  GU450267;  GU450268;  GU450269;  GU450270;  GU450271;  GU450272
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chromosome Inversion*
Chromosomes / genetics*
Linkage Disequilibrium*
Molecular Sequence Data
Polymorphism, Genetic*
Recombination, Genetic
Sparrows / classification,  genetics*
Grant Support
1R21MH082046/MH/NIMH NIH HHS; R21 MH082046/MH/NIMH NIH HHS; R21 MH082046-02/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Independent fusions and recent origins of sex chromosomes in the evolution and diversification of gl...
Next Document:  Promomycin, a polyether promoting antibiotic production in Streptomyces spp.